Results 81 to 90 of about 1,414,965 (228)

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Effects of tempol on renal medullary tissue hypoxia in an ovine model of Gram‐negative septic acute kidney injury

Experimental Physiology, EarlyView.
Abstract Renal arterial infusion of tempol (RAT) at the onset of Gram‐negative sepsis can prevent sepsis‐induced medullary tissue hypoxia and acute kidney injury (AKI). However, it is not known whether treatment with tempol at a clinically relevant time point of sepsis is similarly effective. Thus, we examined whether tempol can reverse renal medullary
Rachel Peiris, Anton Trask‐Marino, Alemayehu Jufar, Ashenafi H. Betrie, Adam Southon, Sally G. Hood, Rinaldo Bellomo, Abraham H. Hulst, Clive N. May, Connie P. C. Ow, Yugeesh R. Lankadeva   +10 more
wiley   +1 more source

Expression characteristics of dual‐specificity phosphatase 2 and hypoxia‐inducible factor‐1α in acute kidney injury and preliminary study of the effect of dual‐specificity phosphatase 2 on HK‐2 cells

Experimental Physiology, EarlyView.
ABSTRACT Acute kidney injury (AKI) is a global health problem with significant long‐term harm if the prognosis is poor. Dual‐specificity phosphatase 2 (DUSP2) is involved in key regulatory pathways in several disease processes, but its function in renal pathophysiology is unclear.
Xueqian Chu, Songmin Xue, Lanyan Lin, Xuan Huang, Sisi Chen, Wulaer Adeli, Zulibiya Tuohetiyaer, Suhua Li, Chen Lu   +8 more
wiley   +1 more source

Minimally Invasive Partial Nephrectomy in the Era of Robotic Surgery

, 2021
Objectives: The objectives of the study were to compare the operative features, complication rates, functional, and pathological outcomes of laparoscopic partial nephrectomy (LPN) and robotic-assisted partial nephrectomy (RPN)
GÜDELOĞLU, AHMET, YAZICI, MUSTAFA SERTAÇ, Artykov, Meylis, HABERAL, HAKAN BAHADIR, BİLEN, CENK YÜCEL   +4 more
core   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

Current status of robot-assisted partial nephrectomy

, 2012
What's known on the subject? and What does the study add? The use of robotic assistance for the partial nephrectomy procedure has emerged as an alternative that may help some of the technical challenges of laparoscopic partial nephrectomy.
Ahmed, Kamran, Dasgupta, Prokar, Kooiman, Gordon, Khan, Mohammed Shamim, Challacombe, Ben, Gohil, Rishma   +5 more
core   +1 more source

The proportion of radical nephrectomy versus partial nephrectomy in patients with unilateral renal cell carcinoma [PDF]

, 2016
Department of Oncology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, The 6th International Medical Congress for Students and Young Doctors, May 12-14, 2016Introduction: The goal of this review is to ...
Rogac, Igor
core   +1 more source

Slow calcium removal contributes to impaired lusitropic response to β‐adrenergic stimulation in HFpEF mice

The Journal of Physiology, EarlyView.
Abstract figure legend Heart failure with preserved ejection fraction (HFpEF) is the most common form of heart failure, yet major gaps remain in our understanding of its underlying mechanisms, disease progression and effective treatment strategies. Mice with HFpEF exhibited exercise intolerance and diastolic dysfunction in vivo, while isolated hearts ...
Tamzin Zawadzki, Diana S. Usai, Sif G. Kaad, Katrine H. Rasmussen, Mie S. Larsen, Jens C. B. Jacobsen, Morten B. Thomsen   +6 more
wiley   +1 more source

Curative‐Intent Pancreatectomy for Pancreatic Metastasis From Renal Cell Carcinoma 30 Years After Nephrectomy Following Lenvatinib Plus Pembrolizumab Therapy: A Case Report

IJU Case Reports, Volume 9, Issue 6, November 2026.
ABSTRACT Introduction Renal cell carcinoma (RCC) is the most common primary site of pancreatic metastases, and complete resection confers a favorable prognosis. Lenvatinib plus pembrolizumab (LEN + PEM) is standard first‐line therapy for advanced RCC; however, induction therapy before resection of pancreatic metastasis has not been reported.
Yuta Kaneko, Reo Kotorii, Kaishi Shimizu, Kazuma Miura, Yosuke Nakanishi, Ken Nakamura, Seiya Hattori, Yasuto Yagi, Toru Nishiyama, Tetsuo Momma   +9 more
wiley   +1 more source

Stage IA papillary and chromophobe renal cell carcinoma: effectiveness of cryoablation and partial nephrectomy

Insights into Imaging
Objectives To evaluate the effectiveness of cryoablation compared to partial nephrectomy in patients with stage IA papillary and chromophobe renal cell carcinoma (pRCC; chRCC).
Annemarie Uhlig, Johannes Uhlig, Brian Shuch, Hyun S. Kim   +3 more
doaj   +1 more source