Results 201 to 210 of about 2,146,795 (300)

Assessment of Sleep, Cognitive Performance, and Circulating Cytokines in Adults with Chronic Rhinosinusitis. [PDF]

Diagnostics (Basel)
Nolte R, Moore DL, Huang Y, Maharana S, Ouyang B, Sharma S, Fekry B, Patel EA, Batra P, Mahdavinia M.   +9 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Reply to Topaz and Bahl: Interpreting a post-2022 lexical shift in academic prose. [PDF]

Proc Natl Acad Sci U S A
Siler K.
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Copanlisib in combination with nivolumab formicrosatellite stable colorectal cancer: a phase 1/2 trial. [PDF]

Nat Commun
Christenson ES, Wala JA, Parkinson R, Collins NB, Jakubowski C, Lin JR, Qian K, Lu J, Wang H, Ho WJ, Chan S, Kulikowicz E, Klein R, Cetasaan Y, Johnson E, Berg M, Meyerhardt JA, Le DT, Schlechter BL, Browner I, Zheng L, Singh H, Donehower R, Jaffee EM, Sorger PK, Giannakis M, Azad N.   +26 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Automated montaging and contrast stretching of adaptive optics ophthalmoscope images. [PDF]

Biomed Opt Express
Ayubi GA, Kunala K, Dubra A.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Neurofascin 140-Positive Sensory Ataxic Variant of Guillain-Barré Syndrome in a Patient with Membranous Nephropathy. [PDF]

Ann Indian Acad Neurol
Naaz S, Turaga SP, Chamathi T, Manne N, Krishna KH.   +4 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source