Results 41 to 50 of about 2,670,857 (211)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Particularities of partial interrogatives in the written didactic discourse [PDF]
Diversitate si Identitate Culturala in Europa, 2022 Partial interrogatives (PIs) are very well highlighted at morphological level and are marked by the occurrence of the interrogative word. Therefore, they are best represented in the didactic discourse.
Constantin-Georgel STOICA
doaj
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Text Classification Using Word-Based PPM Models [PDF]
Computer Science Journal of Moldova, 2006 Text classification is one of the most actual among the natural language processing problems. In this paper the application of word-based PPM (Prediction by Partial Matching) model for automatic content-based text classification is described.
Victoria Bobicev
doaj
Journal of Function Spaces and Applications, 2012 The main aim of this paper is to prove that the logarithmic means of quadratical partial sums of the double Walsh-Kaczmarz series does not improve the convergence in measure.
Ushangi Goginava, Károly Nagy
doaj +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Emotion in Chinese Words Could Not Be Extracted in Continuous Flash Suppression
Frontiers in Human Neuroscience, 2019 Previous studies have demonstrated the automatic vigilance effect for faces and pictures and have attributed it to the brain’s prioritized unconscious evaluation of early evolutionary stimuli that are critical to survival.
Kaiwen Cheng +5 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source