Results 81 to 90 of about 1,520,742 (210)

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

open access: yesAdvanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao   +7 more
wiley   +1 more source

Proxy Blind Signature Scheme [PDF]

open access: yes, 2005
Blind signature is the concept to ensure anonymity of e-coins. Untracebility and unlinkability are two main properties of real coins, which require mimicking electronically.
Amit K Awasthi, Sunder Lal
core   +1 more source

New threshold partially blind signature scheme without trusted center [PDF]

open access: yes, 2009
基于间隙dIffIE-HEllMAn(gdH)群的特点,首先提出了一个有效的基于身份的部分盲签名方案,能够防止私钥产生中心(Pkg)伪造签名。而后用所提的部分盲签名方案构造了基于身份的新型门限部分盲签名方案。文中的构造思想主要基于fEldMAn的可证实秘密共享方案,具有实现简单但安全性高的特点。到目前为止,该方案是第一类用双线性对来构造的基于身份的门限部分盲签名方案。分析表明,所提方案具有部分盲性、不可伪造性和强壮性等特性,是安全、有效的。An efficient ID-based partially ...
吴顺祥, 农强, 郝艳华
core  

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

open access: yesAdvanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale   +6 more
wiley   +1 more source

Leakage-Resilient Lattice-Based Partially Blind Signatures [PDF]

open access: yes, 2019
Blind signature schemes (BSS) play a pivotal role in privacy-oriented cryptography. However, with blind signature schemes, the signed message remains unintelligible to the signer, giving them no guarantee that the blinded message he signed actually ...
D. Hristu-Varsakelis   +3 more
core   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

open access: yesAdvanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj   +25 more
wiley   +1 more source

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

open access: yesAdvanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu   +7 more
wiley   +1 more source

A New Blind Signature Based on the Discrete Logarithm Problem for Untraceability

open access: yes, 2010
[[abstract]]How to design a blind signature based on the discrete logarithm for untraceability is still a field in need of cultivation.
Cheng-Chi Lee; Min-Shiang Hwang; Wei-Pang Yang
core  

PDGFRα+/Integrin α2+ Fibroblasts Orchestrate Tumor Budding in Oral Squamous Cell Carcinoma via Mechano‐Metabolic Symbiosis: E‐Cadherin/Integrin α2β1 Adhesion and Mitochondrial Transfer

open access: yesAdvanced Science, EarlyView.
PDGFA/PDGFRα signaling recruits CAFs to OSCC nests, and CAF‐OSCC contact drives tumor budding invasion. Mechanistically, heterotypic adhesion via E‐cadherin/integrin α2β1 activates YAP signaling in OSCC cells, inducing EMT. Concurrently, CAFs transfer mitochondria through TNTs, supplying ATP to fuel invasion.
Yufang Liu   +17 more
wiley   +1 more source

A New Blind Signature Based on the Discrete Logarithm Problem for Untraceability

open access: yes, 2012
[[abstract]]How to design a blind signature based on the discrete logarithm for untraceability is still a field in need of cultivation.
黃明祥;Hwang, Min-Shiang
core  

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