Results 31 to 40 of about 34,564 (258)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Full-dimensional complex coherence properties tomography for multi-cipher information security

Opto-Electronic Advances
Optical coherence is a fundamental property of light, playing a key role in understanding interference, propagation, and light-matter interactions for both classical and quantum light. Measuring the coherence properties of an optical field is crucial for
Yonglei Liu, Siting Dai, Yimeng Zhu, Yahong Chen, Peipei Peng, Yangjian Cai, Fei Wang   +6 more
doaj   +1 more source

Unidirectional imaging with partially coherent light

Advanced Photonics Nexus
Unidirectional imagers form images of input objects only in one direction, e.g., from field-of-view (FOV) A to FOV B, while blocking the image formation in the reverse direction, from FOV B to FOV A. Here, we report unidirectional imaging under spatially partially coherent light and demonstrate high-quality imaging only in the forward direction (A-> ...
Guangdong Ma, Che-Yung Shen, Jingxi Li, Luzhe Huang, Çagatay Isil, F. Onuralp Ardic, Xilin Yang, Yuhang Li 0003, Yuntian Wang, Md Sadman Sakib Rahman, Aydogan Ozcan   +10 more
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Coherent Matrix-Based Approach for Evaluation of First-Order Speckle Intensity Statistics and Its Application for Speckle Suppression

IEEE Photonics Journal, 2022
The existing approach for evaluating the statistical characteristics of speckle intensity distribution is applicable only to completely decorrelated laser beams.
Qiyong Xu, Anatoliy Lapchuk, Zichun Le, Di Cai, Jun Zhou, Zongshen Liu, Ivan Gorbov, Andriy Kryuchyn   +7 more
doaj   +1 more source

Invariant degrees of coherence of partially polarized light

Optics Express, 2005
The spatio-temporal properties of partially polarized light are analyzed in order to separate partial polarization and partial coherence. For that purpose we introduce useful invariance properties which allow one to characterize intrinsic properties of the optical light independently of the particular experimental conditions. This approach leads to new
Réfrégier, Philippe, Goudail, François   +1 more
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Quantitative Phase Contrast Microscopy with Optimized Partially Coherent Illumination

Photonics, 2023
This paper presents a partially coherent illumination quantitative phase contrast microscopic (PCI-QPCM) prototype. In the PCI-QPCM prototype, the light scattered by a rotating diffuser is coupled into a multi-mode fiber, and the output light is used as ...
Kequn Zhuo, Yang Wang, Ying Ma, Sha An, Zeev Zalevsky, Juanjuan Zheng, Peng Gao   +6 more
doaj   +1 more source