Results 121 to 130 of about 45,393 (304)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A Study on Partially Ordered Sets
, 2020 In this paper, the notion of derivation on partially ordered sets or posets is introduced and studied. Several examples of posets are presented. The properties of the fixed points based on the derivations are investigated.
Myat Thit Soe
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Dynamic Programs on Partially Ordered Sets
SIAM Journal on Control and OptimizationWe introduce a framework that represents a dynamic program as a family of operators acting on a partially ordered set. We provide an optimality theory based only on order-theoretic assumptions and show how applications across almost all subfields of dynamic programming fit into this framework.
Thomas J. Sargent, John Stachurski
openaire +3 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
RAMSEY NUMBERS FOR PARTIALLY-ORDERED SETS
, 2015 We present a refinement of Ramsey numbers by considering graphs with a partial ordering on their vertices. This is a natural extension of the ordered Ramsey numbers. We formalize situations in which we can use arbitrary families of partially-ordered sets
Christopher Cox, Derrick Stolee
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
On q-analogues of partially ordered sets
Journal of Combinatorial Theory, Series A, 1995 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +1 more source
Topological dualities and completions for (distributive) partially ordered sets [PDF]
, 2015 This PhD thesis is the result of our research on duality theory and completions for partially ordered sets. A first main aim of this dissertation is to propose different kind of topological dualities for some classes of partially ordered sets and a ...
González, Luciano J.
core