Results 131 to 140 of about 1,162,426 (279)

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

La politique du terrain brûlé

open access: yesSociologies, 2007
The paper, based on an ethnography of a « mined field » in a school of relegation, deals about some ethnographical traps and ethical dilemmas of the searcher « trapped » in the social network he’s studying, as Everett C. Hughes suggested.
Philippe Vienne
doaj  

Who wants to be a Physical Education Teacher? A Case Study of a Non-Traditional Undergraduate Student in a Physical Education Teacher Education Program [PDF]

open access: yes, 2011
Forty percent of undergraduate students are non-traditional students. The purpose of this study was to identify what attracted the participant to physical education, identify what situational/social factors facilitated the career choice, and the beliefs ...
Ronspies, Scott
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conducting an Unplanned Participant Observation: The Case of a Non-Birder in Bird Watchers' Land

open access: yesForum: Qualitative Social Research, 2016
This article describes two participant observations of birdwatchers, which occurred by serendipity. Characteristics of personal and interpersonal behavior patterns are identified and illustrated.
Roni Berger
doaj  

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Perceber a diferença: a observação participante enquanto metodologia na investigação sócio-espacial

open access: yesCidades, Comunidades e Território
This essay aims to discuss how it is possible to work with the perception of axes of differentiation in contexts of socio-spatial research, contributing to the construction of the field of Urban Planning, which has experienced constant epistemological ...
Gabriel Barth da Silva, Júlia Silveira
doaj  

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