Results 41 to 50 of about 9,995 (264)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
İstisnâ‘ Akdi ve Modern Dönem İslâmî Finans Uygulamalarındaki Yeri
İlahiyat Tetkikleri Dergisi, 2020 İstisnâ‘ akdi klasik fıkıh eserlerinde yerini bulan ve Hz. Peygamber döneminden itibaren insanlar arasında yaygın olarak kullanılan bir akittir. Fıkhın gelişimiyle birlikte bu akitle ilgili de geniş bir bilgi birikimi oluşmuştur.
Yunus Araz
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Mit Ghamr Savings Bank: A Role Model or an Irreplicable Utopia?
İnsan & Toplum, 2018 Despite Mit Ghamr Savings Bank being established in 1963 in Egypt and being commonly mentioned as the first example of Islamic banking in the world, it is yet to be analysed in depth.
Zeyneb Hafsa Orhan
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Communication and performance in Bank–Fund joint participation [PDF]
Research in Economics, 2015 Abstract In this paper I relate Bank–Fund performance to their willingness (or ability) to communicate. I find evidence that a Bank–Fund simultaneous loan is associated to an increase in economic growth and that such effect is diminished by factors preventing full communication, such as the degree of Bank-Fund competition and the salience of ...
openaire +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Cumhuriyet İlahiyat DergisiTarih boyunca bireyler, finansman ihtiyaçlarını karşılamak amacıyla farklı yöntemler geliştirmiştir. Bunlar arasında en yaygın kullanılanlardan biri olan borç ilişkisine dayalı yöntemler, konvansiyonel bankacılığın ortaya çıkışıyla birlikte büyük ölçüde ...
Yunus Akyüz
doaj +1 more source