Results 111 to 120 of about 647,785 (290)

Building Systemic Practice Into Evaluation Of Knowledge Management Tools [PDF]

, 2002
In the absence of any truly systemic approach to IS evaluation, an approach to evaluation of knowledge management tools is described. This uses co-operative inquiry as a participatory action research framework. Evaluation of knowledge management tools is
Savory, Clive
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Rethinking Territorial Governance in Mountain Areas: the case Study of the Bibans Massif (Algeria)

Journal of Agriculture and Environment for International Development
This article analyzes the complexity of territorial governance in Algerian mountain areas through a case study of the Bibans massif. It reveals a dynamic of territorial devitalization despite a rich potential, primarily due to a sectoral and centralized ...
Salah Chouaki, Fouad Chehat, Mohamed Benedir   +2 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Pitfalls of Participatory Approaches

, 2019
Over recent decades, “participation” has become one of the leading mottos of reform-oriented movements in such diverse fields as democracy, technology, finance, management, mass media, culture, social research methodology and, last but not least, social work. Before our eyes the “change of function” (in the terminology of Karl Mannheim) has taken place:
openaire   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Agent-Based Participatory Simulations: Merging Multi-Agent Systems and Role-Playing Games [PDF]

In 2001, Olivier Barreteau proposed to jointly use multi-agent systems and role-playing games for purposes of research, training and negotiation support in the field of renewable resource management.
Paul Guyot, Shinichi Honiden
core  

Farmer's Eye and Breeder's Eye - Fields of Knowledge Exchange as a Condition of a Participatory Breeding Approach [PDF]

, 2007
With the change to organic agriculture, the diversity of local conditions becomes more important. Local adapted varieties are necessary. But breeding for this demand is not profitable for a conventional breeding strategy.
Timmermann, Martin
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source