When digital technologies stumble: Exnovating for conservation science and practice
Conservation Science and PracticeDigital technologies are rapidly transforming conservation efforts in response to pressing planetary environmental challenges. However, these expanding innovations also introduce significant risks and failures that can deepen existing injustices ...
Danilo Urzedo, Sabrina Chakori
doaj +1 more source
Crafting During Coronavirus: participatory methods with older adults during COVID-19. [PDF]
Z Gerontol Geriatr, 2023 Clarke N.
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Weight of Evidence: Participatory Methods and Bayesian Updating to Contextualize Evidence Synthesis in Stakeholders' Knowledge. [PDF]
J Mix Methods Res, 2022 Dion A +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Using Participatory Methods to Enhance Youth Engagement in Substance Use Research. [PDF]
Health Promot Pract, 2021 Valdez ES, Valdez L, Garcia DO.
europepmc +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Participatory methods in a digital setting: experiences from the co-creation of an eHealth tool for people with chronic obstructive pulmonary disease. [PDF]
BMC Med Inform Decis Mak, 2022 Lundell S +4 more
europepmc +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Participatory Methods in Food Behaviour Research: A Framework Showing Advantages and Disadvantages of Various Methods. [PDF]
Foods, 2021 Onwezen MC, Bouwman EP, van Trijp HCM.
europepmc +1 more source