Results 131 to 140 of about 124,534 (311)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

PARTICIPATORY RESEARCH IN THE MANAGEMENT OF TERRITORIAL DEVELOPMENT. INVESTIGATIONS IN LIVEZILE-RIMETEA MICRO-REGION (2001-2002 and 2007-2008) [PDF]

open access: yes
The aim of this study is to present some important aspects of the way inwhich participatory research may contribute to the management of territorialdevelopment, through the identification of problems and development opportunities in agiven territory.
Mihai Pascaru
core  

Methods for doing participatory media research with youth

open access: yes
This chapter explores the implementation of youth participatory research methods aimed at understanding how young people develop critical media literacy to enhance political engagement and activism. Grounded in the premise that youth are experts in their
Namasinga Selnes, Florence   +5 more
core   +1 more source

Computing for construals in distributed participatory design : principles and tools [PDF]

open access: yes, 2009
Distributed participatory design aspires to standards of inclusivity and humanity in introducing technology to the workplace that are hard to attain. The demands it makes upon the development and use of computing technology are particularly topical, as ...
Beynon, Meurig, Chan, Zhan En
core  

Participatory feedback and dissemination with and for children: reflections from research with young migrants in southern Africa

open access: yes, 2007
In this contribution we discuss the process of feedback and dissemination that we adopted following research with children affected by AIDS in southern Africa.
Ansell, N   +5 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Participatory video production: An ideal or wishful thinking

open access: yes, 2010
In 2003 participatory video productions were undertaken in Tanzania to support the work of the World Bank under the aegis of the Economic and Social Research Foundation in Tanzania (ESRF).
Mhando, M.
core  

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