Results 71 to 80 of about 75,299 (265)
Urban ScienceIn the 21st century, there has been a concerted effort to undo the automobile-centric urban planning of the 20th century, which has resulted in degraded public spaces that deter citizen permanence.
Tomás Pedro, Daniel Paiva
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Frontiers in Health ServicesIntroductionSoil-transmitted helminths (STH) are parasitic worms that infect nearly a quarter of the world's population, particularly those living in communities without access to adequate water, sanitation, and housing.
Arianna Rubin Means +13 more
doaj +1 more source
Participatory methods broaden research by directly engaging communities in knowledge production. This chapter provides an overview of the importance, guidelines, and ethical considerations of participatory methods for researchers who are interested in employing a collaborative approach to address social and biophysical environmental issues.
openaire +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Ripple Effects Mapping Within a Process Evaluation of Sport for Development Provision in England
Social InclusionEvaluating the impact of sport for development is fraught with practical and methodological challenges. The evaluator is often presented with complex and messy social realities compounded by ill‐defined interventions with hard‐to‐follow outcomes. Further,
Jase Wilson, Dan Bates
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
EducarThis empirical study examines a topic of great relevance to education researchers, policymakers and practitioners worldwide: school transitions. Specifically, it focuses on the role and impact of transition teachers in Scotland, staff employed solely to
Neil Hume
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source