Results 91 to 100 of about 124,534 (311)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Improving the Walkability of High Streets: A Participatory Approach Using Biosensing and Scenario Co-Creation

Urban Science
In the 21st century, there has been a concerted effort to undo the automobile-centric urban planning of the 20th century, which has resulted in degraded public spaces that deter citizen permanence.
Tomás Pedro, Daniel Paiva
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Where Participatory Approaches Meet Pragmatism in Funded (Health) Research: The Challenge of Finding Meaningful Spaces

, 2012
The term participatory research is now widely used as a way of categorising research that has moved beyond researching "on" to researching "with" participants.
Cook, Tina, Tina Cook
core   +1 more source

Participatory development of a target policy profile to support soil-transmitted helminth elimination

Frontiers in Health Services
IntroductionSoil-transmitted helminths (STH) are parasitic worms that infect nearly a quarter of the world's population, particularly those living in communities without access to adequate water, sanitation, and housing.
Arianna Rubin Means, Arianna Rubin Means, Kellie List, Amy Roll, Amy Roll, Marie-Claire Gwayi-Chore, Marie-Claire Gwayi-Chore, Shawn Dolley, Holger J. Schünemann, Holger J. Schünemann, Thea C. Norman, Judd L. Walson, Judd L. Walson, Judd L. Walson   +13 more
doaj   +1 more source

Making sense of environmental values: a typology of concepts

Ecology and Society, 2017
Debates about environmental values and valuation are perplexing, in part because these terms are used in vastly different ways in a variety of contexts. For some, quantifying human and ecological values is promoted as a useful technical exercise that can
Marc Tadaki, Jim Sinner, Kai M. A. Chan
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Assessing Participatory Development Processes Through Knowledge Building

, 2008
Participatory development is seen by many to be the answer to the issues of ineffectiveness and insustainability which plague externally-imposed international community development. Critics discount this, questioning the inclusivity and sustainability of
Bleckley, David
core  

36. Participatory methods

Participatory methods broaden research by directly engaging communities in knowledge production. This chapter provides an overview of the importance, guidelines, and ethical considerations of participatory methods for researchers who are interested in employing a collaborative approach to address social and biophysical environmental issues.
openaire   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source