Results 71 to 80 of about 124,534 (311)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Participatory Methods in the Analysis of Poverty: A Critical Review [PDF]

This paper reviews and analyses the literature on participatory methods in poverty analysis. The popularity of participatory poverty assessments has greatly increased in the last decade, and a growing number of development agents is adopting some form of
Caterina Ruggeri Laderchi
core  

Structuring Future Social Relations: The Politics of Care in Participatory Practice [PDF]

, 2014
This paper explores the political shifts that take place in participatory design (PD) when the focus is upon co-designing ongoing future societal relations, beyond the immediacy of designing objects or services during project-time.
Yoko Akama, Yoko Akama (16244720), Ann Light (4461424), Akama, Yoko, Light, Ann, Ann Light   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Using Participatory Design Methods to Engage the Uninterested

, 2012
Engaging young people on issues relating to mental health can be challenging. Although young people have their own health and wellbeing goals, their perception of these issues can be radically different to those of mental health professionals.
Penny Hagen, Kitty Rahilly, Nicholas, M, Hagen, P, Swainston, N, Mariesa Nicholas, Nathalie Swainston, Rahilly, K   +7 more
core   +1 more source

Exploring participatory design for SNS-based AEH systems [PDF]

, 2012
The rapidly emerging and growing social networking sites (SNS) offer an opportunity to improve adaptive e-learning experience by introducing a social dimension, connecting users within the system.
Al Qudah, Dana, Al-Qudah, D, Shi, L, Shi, Lei, Cristea, A, Cristea, Alexandra I.   +5 more
core   +1 more source

Assessment of the vulnerability of coastal agriculture to seawater intrusion using remote sensing, GIS, and Multi-Criteria Decision Analysis

International Journal of Digital Earth
The Philippines heavily relies on crop production, with a significant portion cultivated in coastal agricultural areas. However, these farmlands are impacted by salinity intrusion, which adversely affects agricultural productivity.
Nerissa Gatdula, Ariel Blanco
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Participatory budgeting - a neighbourhood manager's perspective [PDF]

, 2010
This study reports the impact of the requirement to consult with citizens on budgeting decisions through Participatory Budgeting. The Duty to Involve agenda was imposed as a legal duty in April 2009 on all local authorities set out by the Labour ...
Naylor, Sara
core