Results 161 to 170 of about 103,804 (258)

A participatory research project on health issues at the dog-human interface in seven indigenous communities in Northern Canada: how successful was participation? [PDF]

Int J Circumpolar Health
Saint-Charles J, Simon A, Druetz T, Ravel A.   +3 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

A community-based participatory research and community health workers-led health education strategy for schistosomiasis control among schoolchildren in Pemba Island, Zanzibar: a cluster-randomized trial. [PDF]

Infect Dis Poverty
Li X, Wang Y, He M, Mohammed SJ, Khamis KS, Wang X, Zhou X, Xu Z, Shi L, Suleiman MM, Khamis MA, Dai Y, Sun J, Yang K, Li Y, Huang Y.   +15 more
europepmc   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Detection of pathogenic leptospires in water bodies in neighborhoods vulnerable to flooding, through a participatory research approach in Santa Fe (Argentina). [PDF]

PLOS Glob Public Health
Carletti JV, Rueda EC, Sesma J, Cristaldi MA, Ricardo T, Medrano C, Avalos CA, Mendicino DA, Previtali MA.   +8 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Patients' Associations as Co-Creators of Knowledge: Insights From a Community-Based Participatory Research Study (ProSafe Project). [PDF]

Health Sci Rep
Moretti F, Colpo S, Montresor S, Facchinello D, Robello R, Mazzi M, Tardivo S, Stagi L, Stefano L, Zotti A, Ambroso L, Destro C, Leone S, Petruzzelli D, Moretti U, Rimondini M.   +15 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Community-based participatory research: a lifeline to achieve people-centered care. [PDF]

Front Public Health
Rosa WE, Santos J, Agbeko AE, Barksdale CL, Carvajal S, Dillard D, Elk R, Emrick GE, Gany F, Gazaway S, Leng J, Mazor M, Moore-Monroy M, Salins N, Godwin K, Bhoo-Pathy N, Borda JP, Fernández-González L, Mann E, Shapiro GK, Allsop MJ, Pérez-Stable EJ.   +21 more
europepmc   +1 more source