This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Pakistani families with disabled children are among the most disadvantaged population groups in the UK.
Kramer-Roy, Debbie
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Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Strategies for high-quality community-based participatory research partnerships in public health research. [PDF]
D'Agostino EM +11 more
europepmc +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Editorial: Examining community-engaged and participatory research programs and projects
Milton (Mickey) Eder +3 more
doaj +1 more source
Progress Through Engagement: A Systematic Review and Thematic Synthesis of Qualitative Community-Based Participatory Research in Vision Impairment. [PDF]
Tavoulari A +3 more
europepmc +1 more source
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
A participatory research project on health issues at the dog-human interface in seven indigenous communities in Northern Canada: how successful was participation? [PDF]
Saint-Charles J +3 more
europepmc +1 more source
A Conceptual Framework for Guiding the Participatory Development of Agricultural Decision Support Systems [PDF]
Scientists develop decision support systems (DSSs) to make agricultural science more accessible for farmers and extension officers. Despite the growing use of participatory approaches in agricultural DSS development, reflection on this endeavour is ...
Emma Jakku, Peter Thorburn
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