Results 171 to 180 of about 758,673 (282)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Using Community-Based Participatory Research Strategies to Promote Liver Cancer Prevention. [PDF]

Soc Sci
Zhu L, Lu W, Yeh MC, Ma GX, González ET, Traub K, Fraser MA, Rubio-Torio N, Wong A, Tan Y.   +9 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Complex, multilevel barriers and solutions for nutrition security in the USA: a community-based participatory research approach. [PDF]

BMJ Public Health
Linde BD, Meadows RJ, Maese E, Miljanich C, Frome H, Dufrene M.   +5 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Participatory Evaluation of Participatory Research

Participatory Evaluation of Participatory Research
この講演では、1)研究・開発事業における評価という役割の変化、2)事業評価における参加型アプローチという新しい手法の誕生と3)参加型研究の評価という新たな分野への朝鮮とその課題について述べる。キーとなる重要な概念と実践方法を理解していただくために、アジアで実際に行われた農業研究と開発関連の実例を使いながら話をすすめていきたい。研究・開発事業では、評価は、説明責任と透明さを確実なものとするためのただ単なる手段として今までみなされていた。評価は事業がその目的を達成したか、資源を有効に使うことができたかどうかを図るためによく使われるが、これは公の場において公正さの審査を受けるためである。ほとんどの評価事業はプロジェクトの提案者、実施者とドナーのニーズにこたえるように組み立てられている。評価は、私意のない ...
openaire  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Empowering promotoras through community-based participatory research in Latinx and Indigenous Mexican communities during the COVID-19 pandemic. [PDF]

Front Public Health
Cheney AM, Li E, Ortiz G, Pazos A, Bell C, Vázquez E, Delgado L, Zimmer A, Simonoski Ú, Muñante Navarro R, Pozar M.   +10 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Developing and applying the 'Participatory Research to Action Framework' for meaningful engagement of experts-by-experience in applied health services research: a case study approach. [PDF]

Res Involv Engagem
L Giosa J, Evans C, Cardozo V, Holyoke P.   +3 more
europepmc   +1 more source