Results 61 to 70 of about 765,758 (302)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Improving NGOs’ participation in implementing HIV preventive interventions: a case of adolescents with high-risk behaviors in Iran

BMC Public Health
Background The study aimed to identify the obstacles that NGOs face in their participation in implementing HIV preventive interventions among adolescents with high-risk behaviors in Iran and to propose interventions to enhance their involvement.
Haniye Sadat Sajadi, Laleh Ghadirian, Azadeh Sayarifard, Fatemeh Rajabi, Maryam Nazari, Narges Rostamigooran, Nina Loori, Haniyeh Haji Abolhasan Memar, Mojgan Farshadi, Parvin Afsar Kazerooni, Maryam Sargolzaeemoghaddam, Reza Majdzadeh   +11 more
doaj   +1 more source

CGIAR Systemwide Program on Participatory Research and Gender Analysis for Technology Development and Institutional Innovation [PDF]

, 2004
This paper, prepared by the CGIAR Systemwide Program on Participatory Research and Gender Analysis, analyzes the four constraining factors (listed below) in the context of their implications to agricultural research and development. 1. Limitations in the
CGIAR Systemwide Program on Participatory Research and Gender Analysis for Technology Development and Institutional Innovation
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Toward Digital, Critical, Participatory Action Research: Lessons From The #BarrioEdProj [PDF]

, 2014
The Education in our Barrios project, or #BarrioEdProj, is a digital critical participatory action research (D+CPAR) project that examines the interconnected remaking of public education and a New York City Latino core community in an era of racial ...
Mayorga, Edwin
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Troubling futures: can participatory design research provide a generative anthropology for the 21st century? [PDF]

, 2015
This essay argues there is value in considering participatory design as a form of generative anthropology at a time when we recognise that we need not only to understand cultures but to change them towards sustainable living.
Light, Ann
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What’s going on in my city? Recommender systems and electronic participatory budgeting [PDF]

, 2018
In this paper, we present electronic participatory budgeting (ePB) as a novel application domain for recommender systems. On public data from the ePB platforms of three major US cities – Cambridge, Miami and New York City–, we evaluate various methods ...
Marsal-Llacuna Maria-Lluïsa, Miori Vittorio, Nelimarkka Matti, Ning Xia, Peixoto Tiago, Álvarez-Sabucedo Luis   +5 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A participatory action research study of key account management changes [PDF]

, 2006
Pure Participatory Action Research projects in the IMP research tradition are rather rare. This paper describes both the process and the outcomes of such a project carried out for a major business to retail firm in the UK.
Easton, G, Gilchrist, A, Lenney, P
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