Results 101 to 110 of about 53,501 (264)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Gamification of Participatory Science and Digital Transition in Mountain Areas: The Case of the Mercantour Bearded Vulture Network

Revue de Géographie Alpine
Participatory science is an alternative to certain mountain practices. At local, it rests on collaborations between scientists and citizens. In France, the Mercantour National Park, a unique territory, is an interesting case for study.
Alain Schoeny
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

From seeds to scenarios: Co‐creating brighter marine futures in Nova Scotia, Canada

Ecosphere
Marine ecosystems underpin human well‐being and offer essential ecosystem services but continue to face challenges due to human‐induced pressures. In Nova Scotia, where cultural identity and economic resilience are dependent on marine resources, there is
Suchinta Arif, Rachael Cadman, Chad Simmons, Zoya Tyabji, Ainhoa Fournier, Marijke deVet, Ross Claytor, Corrine Cash, Joseph Pratt, Krista Collier‐Jarvis, Ronnie Noonan‐Birch, Paige McCarthy, Scott McIlveen, Emily Baker, Ben Shellnut, Leah Creaser, Emily Roy, Macy Giles, Frank Kwaku Aazore, Derek Tittensor, Megan Bailey   +20 more
doaj   +1 more source

Implementing citizen science activities for climate action: the I-CHANGE Day

Frontiers in Environmental Science
The H2020 I-CHANGE project (Individual Change of HAbits Needed for Green European transition) aims to actively engage citizens in tackling climate change through citizen science practices.
Laura Esbrí, Laura Esbrí, Montserrat Llasat-Botija, Montserrat Llasat-Botija, Maria Carmen Llasat, Maria Carmen Llasat, Yolanda Sola, Nicola Loglisci, Erika Brattich, Sandra Racionero, Gert-Jan Steeneveld, Anna Mölter, Antonella Galizia, Lara Polo, Esther E. M. Peerlings, Carlo Cintolesi, Francesco Barbano, Muhammad Adnan, Lien Aerts, Pinhas Alpert, Gabriel Campos, Bio Mohamadou Torou, Silvana Di Sabatino, Antonio Parodi   +23 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Color aberration in malachite kingfishers: Insights from community science observations in Queen Elizabeth National Park, Uganda

Ecology and Evolution
Color aberrations in birds corresponds with important ecological functions, including thermoregulation and physiological impacts, camouflage and increased predation, and social interactions with conspecifics. Color aberrations in birds have been reported
Bethany H. Warner, Katherine C. B. Weiss, Maximilian L. Allen   +2 more
doaj   +1 more source