Results 41 to 50 of about 170,044 (337)

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

Particle Accelerators [PDF]

open access: yes, 1955
In the most general sense, an accelerator is any device designed to give kinetic energy to ions or electrons. According to this definition the earliest cathode ray and canal ray tubes, made before the turn of the century were accelerators, the same principle is used in the x-ray tube, the cathode ray oscilloscope, the mass spectrograph, the electron ...
openaire   +4 more sources

Strip-based Scintillation Detector for Dual-readout High-granularity Calorimetry [PDF]

open access: yesEPJ Web of Conferences
New calorimeter technology is being developed for future collider experiments. We are developing a calorimeter that integrates two technologies, a high-granularity calorimeter and a dual-readout calorimeter, and has high time resolution at a picosecond ...
Ogawa Hiroyasu   +9 more
doaj   +1 more source

Accelerator modes of square well system

open access: yes, 2005
We study accelerator modes of a particle, confined in an one-dimensional infinite square well potential, subjected to a time-periodic pulsed field. Dynamics of such a particle can be described by one generalization of the kicked rotor. In comparison with
Benkadda   +20 more
core   +1 more source

Beam Cleaning and Collimation Systems [PDF]

open access: yes, 2016
Collimation systems in particle accelerators are designed to dispose of unavoidable losses safely and efficiently during beam operation. Different roles are required for different types of accelerator.
Redaelli, S.
core   +3 more sources

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Beam-Material Interaction [PDF]

open access: yes, 2016
Th is paper is motivated by the growing importance of better understanding of the phenomena and consequences of high- intensity energetic particle beam interactions with accelerator, generic target , and detector components.
Cerutti, F., Mokhov, N. V.
core   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Challenges of Future Accelerators for Particle Physics Research

open access: yesFrontiers in Physics, 2022
For over half a century, high-energy particle accelerators have been a major enabling technology for particle and nuclear physics research as well as sources of X-rays for photon science research in material science, chemistry and biology.
Stephen Gourlay   +2 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

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