Results 51 to 60 of about 1,317,033 (253)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Pamela: development of the RF system for a non-relativistic non-scaling FFAG [PDF]

, 2009
The PAMELA project(Particle Accelerator For MEdical Applications) currently consists of the design of a particle therapy facility. The project, which is in the design phase, contains Non-Scaling FFAG, particle accelerator capable of rapid beam ...
Vojnovic, B., Barlow, Roger, Pasternak, J., McIntosh, P.A., Witte, H., Aslaninejad, M., Chilton, C., Sheehy, S., Smith, S., Yokoi, T., Machida, S., Cobb, J., Tygier, S.C., Pozimski, J.K., Fenning, R, Beard, C., Gardner, I., Seviour, Rebecca, Peach, K., Kelliher, D.   +19 more
core   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Preconditioned flow as a solution to the hierarchical growth problem in the generalized Lefschetz thimble method

Journal of High Energy Physics
The generalized Lefschetz thimble method is a promising approach that attempts to solve the sign problem in Monte Carlo methods by deforming the integration contour using the flow equation.
Jun Nishimura, Katsuta Sakai, Atis Yosprakob   +2 more
doaj   +1 more source

Implementing NLO DGLAP evolution in parton showers

Journal of High Energy Physics, 2017
We present a parton shower which implements the DGLAP evolution of parton densities and fragmentation functions at next-to-leading order precision up to effects stemming from local four-momentum conservation.
Stefan Höche, Frank Krauss, Stefan Prestel   +2 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Synthesis mechanism from graphene quantum dots to carbon nanotubes by ion-sputtering assisted chemical vapor deposition

Discover Nano
We present the first work of the synthesis mechanism from graphene quantum dots (GQDs) to carbon nanotubes (CNTs) by an ion-sputtering assisted chemical vapor deposition.
Jun Mok Ha, Seoung Ho Lee, Daehyeon Park, Young Jun Yoon, In Mok Yang, Junhyeok Seo, Yong Seok Hwang, Chan Young Lee, Jae Kwon Suk, Jun Kue Park, Sunmog Yeo   +10 more
doaj   +1 more source

Development of High-Granularity Dual-Readout Calorimetry with psec Timing [PDF]

EPJ Web of Conferences
Dual-readout and particle flow algorithm (PFA) are technologies proposed for precise jet energy measurement in future colliders. While PFA requires highly granular calorimeters, dual-readout has mainly been used with fiber-based calorimeters that do not ...
Kamiyama Taiki, Freeman James, Gatto Corrado, Jeans Daniel, Li Weiyuan, Matsuoka Kodai, Ogawa Hiroyasu, Ootani Wataru, Suehara Taikan, Takeshita Tohru   +9 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source