Results 71 to 80 of about 2,772,396 (335)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A First Mass Production of Gas Electron Multipliers [PDF]

, 2003
We report on the manufacture of a first batch of approximately 2,000 Gas Electron Multipliers (GEMs) using 3M's fully automated roll to roll flexible circuit production line. This process allows low-cost, reproducible fabrication of a high volume of GEMs
Aidala, Beirle, Benlloch, Buzulutskov, Chechik, Collar, Costa, Derré, Giomataris, Guirl, Li, Oed, Sauli, Sauli, Sauli, Shekhtman   +15 more
core   +2 more sources

Rotating Hayward’s regular black hole as particle accelerator [PDF]

, 2015
A bstractRecently, Bañados, Silk and West (BSW) demonstrated that the extremal Kerr black hole can act as a particle accelerator with arbitrarily high center-of-mass energy (ECM) when the collision takes place near the horizon.
Muhammed Amir, Sushant G. Ghosh
semanticscholar   +1 more source

Preconditioned flow as a solution to the hierarchical growth problem in the generalized Lefschetz thimble method

Journal of High Energy Physics
The generalized Lefschetz thimble method is a promising approach that attempts to solve the sign problem in Monte Carlo methods by deforming the integration contour using the flow equation.
Jun Nishimura, Katsuta Sakai, Atis Yosprakob   +2 more
doaj   +1 more source

Development of High-Granularity Dual-Readout Calorimetry with psec Timing [PDF]

EPJ Web of Conferences
Dual-readout and particle flow algorithm (PFA) are technologies proposed for precise jet energy measurement in future colliders. While PFA requires highly granular calorimeters, dual-readout has mainly been used with fiber-based calorimeters that do not ...
Kamiyama Taiki, Freeman James, Gatto Corrado, Jeans Daniel, Li Weiyuan, Matsuoka Kodai, Ogawa Hiroyasu, Ootani Wataru, Suehara Taikan, Takeshita Tohru   +9 more
doaj   +1 more source

LHC signals of triplet scalars as dark matter portal: cut-based approach and improvement with gradient boosting and neural networks

Journal of High Energy Physics, 2020
We consider a scenario where an SU(2) triplet scalar acts as the portal for a scalar dark matter particle. We identify regions of the parameter space, where such a triplet coexists with the usual Higgs doublet consistently with all theoretical as well as
Atri Dey, Jayita Lahiri, Biswarup Mukhopadhyaya   +2 more
doaj   +1 more source

Search prospects for axionlike particles at rare nuclear isotope accelerator facilities [PDF]

, 2023
W. Jang, Doojin Kim, Kyoungchul Kong, Y.-J. Kwon, Jong-Chul Park, Min Sang Ryu, Seodong Shin, R. G. Van de Water, Unki Yang, J. S. Yu   +9 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Transverse Beam Profiles

, 2020
The performance and safe operation of a particle accelerator is closely connected to the transverse emittance of the beams it produces. For this reason many techniques have been developed over the years for monitoring the transverse distribution of ...
Bravin, Enrico
core  

Synthesis mechanism from graphene quantum dots to carbon nanotubes by ion-sputtering assisted chemical vapor deposition

Discover Nano
We present the first work of the synthesis mechanism from graphene quantum dots (GQDs) to carbon nanotubes (CNTs) by an ion-sputtering assisted chemical vapor deposition.
Jun Mok Ha, Seoung Ho Lee, Daehyeon Park, Young Jun Yoon, In Mok Yang, Junhyeok Seo, Yong Seok Hwang, Chan Young Lee, Jae Kwon Suk, Jun Kue Park, Sunmog Yeo   +10 more
doaj   +1 more source