Results 81 to 90 of about 2,772,396 (335)

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Beam-Beam Effects

, 2016
One of the most severe limitations in high-intensity particle colliders is the beam-beam interaction, i.e. the perturbation of the beams as they cross the opposing beams.
Herr, W., Pieloni, T.
core   +1 more source

New constraint on dark photon at T2K off-axis near detector

Journal of High Energy Physics, 2023
The T2K experiment is one of the most powerful long-baseline experiments to investigate neutrino oscillations. The off-axis near detector called ND280 is installed 280 m downstream from the neutrino production target to measure the neutrino energy ...
Takeshi Araki, Kento Asai, Tomoya Iizawa, Hidetoshi Otono, Takashi Shimomura, Yosuke Takubo   +5 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Rotating Ayón-Beato-García black hole as a particle accelerator [PDF]

, 2014
We study the collision of two particles with equal masses moving in the equatorial plane near horizon of the rotating regular Ayon-Beato-Garc´oa (ABG) black hole (BH) and calculate the center- of-mass (CM) energy for the colliding particles for both ...
Sushant G. Ghosh, Pankaj Sheoran, Muhammed Amir   +2 more
semanticscholar   +1 more source

Axion dark matter detection by superconducting resonant frequency conversion

Journal of High Energy Physics, 2020
We propose an approach to search for axion dark matter with a specially designed superconducting radio frequency cavity, targeting axions with masses m a ≲ 10 −6 eV. Our approach exploits axion-induced transitions between nearly degenerate resonant modes
Asher Berlin, Raffaele Tito D’Agnolo, Sebastian A. R. Ellis, Christopher Nantista, Jeffrey Neilson, Philip Schuster, Sami Tantawi, Natalia Toro, Kevin Zhou   +8 more
doaj   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Dark Matter and Collider Searches in $$S_3$$ S 3 -Symmetric 2HDM with Vector Like Lepton

European Physical Journal C: Particles and Fields, 2021
We study the $$S_3$$ S 3 -symmetric two Higgs doublet model by adding two generations of vector like leptons (VLL) which are odd under a discrete $$Z_2$$ Z 2 -symmetry. The lightest neutral component of the VLL acts as a dark matter (DM) whereas the full
Indrani Chakraborty, Dilip Kumar Ghosh, Nivedita Ghosh, Santosh Kumar Rai   +3 more
doaj   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source