Results 61 to 70 of about 1,288,945 (304)

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Accelerator Technology: High Precision Power Converters for Particle Accelerators

open access: yes, 2013
This document is part of Subvolume C 'Accelerators and Colliders' of Volume 21 'Elementary Particles' of Landolt-Börnstein - Group I 'Elementary Particles, Nuclei and Atoms'.
J. P. Burnet   +5 more
core   +1 more source

Making pions with laser light

open access: yesNew Journal of Physics, 2018
The interaction of high intensity short pulse laser beams with plasmas can accelerate electrons to energies in excess of a GeV. These electron beams can subsequently be used to generate short-lived particles such as positrons, muons, and pions. In recent
W Schumaker   +14 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Characterisation of the muon beams for the Muon Ionisation Cooling Experiment [PDF]

open access: yes, 2013
A novel single-particle technique to measure emittance has been developed and used to characterise seventeen different muon beams for the Muon Ionisation Cooling Experiment (MICE).
Adey, David   +633 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

open access: yesFEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai   +8 more
wiley   +1 more source

Investigations on particle dynamics in a high intensity heavy ion linac for inertial fusion [PDF]

open access: yes, 2005
Die Physik intensiver Ionenstrahlen wird zur Zeit für verschiedene neue Hochstrom- und Hochenergie-Beschleunigeranlagen untersucht. Ein kritischer Punkt ist dabei die Minimierung der Strahlverluste, um die Aktivierung der Beschleunigerstruktur zu ...
Parisi, Giovanni
core  

Multi-electron beam generation using co-propagating, parallel laser beams

open access: yesNew Journal of Physics, 2018
High intensity short pulse laser plasma interaction experiments were performed to investigate laser wakefield acceleration (LWFA) in the ‘bubble’ regime. Using a specially designed phase plate, two high intensity laser focal spots were generated adjacent
J Elle   +9 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

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