Results 51 to 60 of about 1,211,649 (237)

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Particle breakage of soil-rock aggregate based on large-scale direct shear tests

open access: yesYantu gongcheng xuebao, 2017
In the direct shear tests on soil-rock aggregate (SRA), particle breakage occurs in micro vision, which will influence its macro mechanical properties. On this basis, the laboratory large-scale direct shear tests and sieving analysis tests are conducted ...
LIU Xin-rong1, 2, TU Yi-liang 1, 2, WANG Peng 1, 2, ZHONG Zu-liang 1, 2, TANG Wen-bin 3, DU Li-bing 1, 2
doaj   +1 more source

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Study on long-term direct shear effects on the particle breakage characteristics of calcium sand

open access: yesShuili Shuiyun Gongcheng Xuebao
The particle breakage characteristics of calcium sand under long-term direct shear are important factors affecting the shear creep deformation of calcium sand.
ZHONG Haoyu, TANG Bin, WANG Yinchuan
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Compaction and Breakage Characteristics of Crushed Stone Used as the Backfill Material of Urban Pavement Subsidence

open access: yesAdvances in Civil Engineering, 2020
The subsidence of urban pavement is becoming frequent accidents, and backfill is the primary means of remedy. Crushed stone is a commonly used aggregate for backfill material in engineering, and its compaction behavior under load needs to be well ...
Zhongbing Cai   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Distribution of Nanoparticles in a Turbulent Taylor–Couette Flow Considering Particle Coagulation and Breakage

open access: yes, 2021
In this paper, the dynamic evolution of nanoparticles in a turbulent Taylor–Couette flow was studied by means of a numerical simulation. The initial particle size was 200 nm, and the volume concentration was 1 × 10−5.
Jianzhong Lin, Ruifang Shi, Hailin Yang
core   +1 more source

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