Results 61 to 70 of about 1,211,649 (237)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Mineral liberation by particle bed breakage

, 1997
The prediction of mineral liberation in mineral processing operations has become of major importance in the last two decades. This is especially the case for comminution processes.
Boland, J., Lim, W., Fandrich, R. G., Bearman, R. A.   +3 more
core   +1 more source

Investigation of railroad ballast particle breakage [PDF]

Pollack Periodica, 2019
Abstract This paper summarizes the authors' up-to-date results in the research topic of railway ballast particles' breakage test with individual laboratory test.
Juhász, Erika, Fischer, Szabolcs
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Experimental study on the particle breakage of calcareous sand

, 2022
This paper reports the results from a series of triaxial compression tests undertaken to provide insight into the particle breakage of a calcareous sand.
Shah Neyamat Ullah (9841577), Youngho Kim (5646020), Yuxia Hu (10929702), Muhammad Hossain (13901010), Li Cheng (228291)   +4 more
core  

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Particle breakage using wet mill, ultrasonic, and hydrodynamic cavitation

, 2023
In-line fluidic devices and mills are often used for controlling crystal size distribution during crystallization. In this work, we investigated the breakage of organic crystals in three particle breakage devices. Paracetamol was selected as a model API (
Gavin Walker (12351430), Vidit Tiwari (17474778), VIVEK RANADE (12349219)   +2 more
core   +2 more sources

Influence of particle breakage on coefficient of earth pressure at rest for coral sand

Yantu gongcheng xuebao
o investigate the influence of particle breakage on the coefficient of earth pressure at rest (K0) of coral sand, this study employs coral sands from the South China Sea for saturated K0 consolidation tests under single-particle-size conditions.
HOU Heying , CHEN Zhipeng , WANG Binghui
doaj   +1 more source