Results 91 to 100 of about 169,131 (312)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

End-to-End Detector Optimization with Diffusion Models: A Case Study in Sampling Calorimeters

Particles
Recent advances in machine learning have opened new avenues for optimizing detector designs in high-energy physics, where the complex interplay of geometry, materials, and physics processes has traditionally posed a significant challenge.
Kylian Schmidt, Krishna Nikhil Kota, Jan Kieseler, Andrea De Vita, Markus Klute, Abhishek, Max Aehle, Muhammad Awais, Alessandro Breccia, Riccardo Carroccio, Long Chen, Tommaso Dorigo, Nicolas R. Gauger, Enrico Lupi, Federico Nardi, Xuan Tung Nguyen, Fredrik Sandin, Joseph Willmore, Pietro Vischia   +18 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Neuromorphic Readout for Hadron Calorimeters

Particles
We simulate hadrons impinging on a homogeneous lead tungstate (PbWO4) calorimeter using GEANT4 software to investigate how the resulting light yield and its temporal structure, as detected by an array of light-sensitive sensors, can be processed by a ...
Enrico Lupi, Abhishek, Max Aehle, Muhammad Awais, Alessandro Breccia, Riccardo Carroccio, Long Chen, Abhijit Das, Andrea De Vita, Tommaso Dorigo, Nicolas Ralph Gauger, Ralf Keidel, Jan Kieseler, Anders Mikkelsen, Federico Nardi, Xuan Tung Nguyen, Fredrik Sandin, Kylian Schmidt, Pietro Vischia, Joseph Willmore   +19 more
doaj   +1 more source

Hybrid tracking detector based on semiconductor and gas technologies

EPJ Web of Conferences, 2017
New Silicon-Gas Pixel Detector (SiGPD) is the result of the further development already proposed Gas-Pixel Detector (GPD). The only disadvantage of GPD was the uncertainty of the particle arriving time.
Bashindzhagyan George, Korotkova Natalia, Romaniouk Anatoli, Sinev Nikolai, Tikhomirov Vladimir   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Measurement of the Differential Production Cross Section of W Bosons and Charge Asymmetry at �s = 7 TeV with the ATLAS Detector [PDF]

, 2012
This document presents a measurement of the production cross section of W bosons and of its charge asymmetry in proton-proton collisions at a centre of mass energy of 7 TeV with the ATLAS detector. These measurements provide information on the momentum
Tsionou, Dimitra
core  

A Capacitive Particle-Analyzing Smoke Detector for Very Early Fire Detection

Sensors
Smoke detectors face the challenges of increasing accuracy, sensitivity, and high reliability in complex use environments to ensure the timeliness, accuracy, and reliability of very early fire detection. The improvement in and innovation of the principle
Boqiang Wang, Xuezeng Zhao, Yiyong Zhang, Zigang Song, Zhuogang Wang   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

EXPERIMENTAL TECHNIQUE TO MEASURE THORON GENERATION RATE OF BUILDING MATERIAL SAMPLES USING RAD7 DETECTOR [PDF]

, 2013
Thoron (220Rn) is the second most abundant radon isotope in our living environment. In some dwellings it is present in significant amount which calls for its identification and remediation. Indoor thoron originates mainly from building materials. In this
Csige, István, Szabó, Zsuzsanna, Szabó, Csaba   +2 more
core   +1 more source