Results 101 to 110 of about 169,131 (312)
Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig +10 morewiley +1 more sourceThe mass-hierarchy and CP-violation discovery reach of the LBNO long-baseline neutrino experiment [PDF]
, 2013 The next generation neutrino observatory proposed by the LBNO collaboration will address fundamental questions in particle and astroparticle physics.Gavrilov, G., A. Ereditato, G. Gavrilov, Tsenov R, J. Sarkamo, Novikov, Y.u., R. Terri, Gorodetzky, P, Agarwalla, SK, W. Bartmann, Gendotti, A, Spooner N, Kryn, D, Magaletti L, Thompson, LF, Giganti C, Sarkamo, J., Crivelli, Paolo, M. Weber, Morgan, B. (Ben), Berardi, V., Ilic J, Loo K, V. Palladino, Sergiampietri, F., Saviano, N., A.M. Blebea-Apostu, Wilson, J.R., Ravonel M, J. Coleman, Cantini, C., Catanesi, M.G., Sanchez, P. D. A., Kudryavtsev, V. A., De Bonis, I, Autiero D, Radicioni, E., I. Bandac, B. Still, Kormos LL, K. Huitu, Sato F, Sgalaberna, D, Radicioni E, Angus, D., Thompson, L. F., I. Bertram, Ereditato, A, J.-M. Levy, Rummukainen K, Agarwalla, Sanjib Kumar, M.G. Catanesi, Quinto, M, Litchfield R, C. Cantini, Horikawa, Sosuke, Resnati F, Sakashita K, S. Emery, A. Gendotti, Pascoli, S, Noah E, P. Ballett, Brancus, I., F. Cafagna, Ioannisian, AN, Kalliokoski, T., Sakashita, K, Hissa, J, Buizza-Avanzini, M., Wilson JR, Eliseev, A., Agarwalla, S.K., Boyd S, Y. Karadzhov, H. Vincke, Spooner, N.j.c., Velten, P., Vacheret A, Bartmann W, Crivelli, P., Cervera Villanueva, Anselmo, A.J. Finch, Palladino, V., C. Densham, Barr, G., Tonazzo A, Ariga, T, Wiebusch, C., et al., Matveev, V., Kopylov, A.N., F. Velotti, Gomez, J. J., T. Esanu, Bogomilov, M, Slupecki, M, Cata-Danil, G., L.L. Kormos, Mavrokoridis K, Grant, Nick, I. Efthymiopoulos, Palladino, V, Di Luise S, Murphy S, M. Murdoch, M. Valram, M. Zito, Mercadante, A., Payne D, O. Caretta, E. Radicioni, K. Tuominen, Chesneanu, D., I. Kreslo, N.J.C. Spooner, Sgalaberna, Davide, Dumarchez, J., Pistillo, C, Loo, K., Horikawa, S, Kokko, E, Hierholzer, M, P. Velten, Christodoulou G, V. Matveev, Scantamburlo, E, Martin Mari, C., Mercadante A, Cervera, A., Asfandiyarov R, Haesler, A, Kokko, E., Still B, Eliseev A, Banerjee, Daipayan, Matveev V, Nesterenko D, Barr, G, Ariga, A, Rummukainen, K., Vasseur, G, Kainulainen K, Loo, K, Coleman, J., Korzenev, A, F. Resnati, Buizza-Avanzini, M, Stahl, Achim, Wu, S, D. Kryn, S.K. Agarwalla, Saftoiu, A, Ratoff P, Mirizzi A, Catanesi, M. G., Strauss, T., Bogomilov, M., Viant, T, G. Christodoulou, K. Mursula, Novikov, Yu., Luise, SD, Catanesi M, Touramanis C, De Jong J, A. Tonazzo, Litchfield, R. P., M. Hierholzer, R.P. Litchfield, J. Zalipska, Haesler, A., Pistillo C, H. O’Keeffe, Erykalov AN, Kormos, Laura, Wiebusch C, M. Rayner, Margineanu R, Trzaska W, M. Buizza-Avanzini, Hasegawa T, Blebea-Apostu AM, Pectu M, Enqvist, T, Galymov, V., N. McCauley, Sakashita, K., Kudryavtsev, VA, A.N. Kopylov, Del Amo Sanchez, P., Boyd, S, S. Pascoli, Zito, M, Terri, R., Magaletti, L., Kumpulainen, J, Oprima, A, Periale, L, Pessard H, Cantini, Cosimo, Valram M, Terri, R, J. Dumarchez, Popov, B, Enqvist, K, Mitrica, B., Kopylov, A. N., Di Lodovico F, Vanucci, F, Stoica, S, D. Autiero, Kuusiniemi P, Tuominen, K, Fitton M, W.H. Trzaska, P. Crivelli, T. Enqvist, Szeptycka, M., Finch A, Gomoiu, C. M., Epprecht, L, Agarwalla S, O'Keeffe H, Przewlocki P, Trzaska, WH, Trzaska, W.H., L. Agostino, Angus, D, Bertram, I, Y. Papaphilippou, Toma, G., A.N. Ioannisian, Duchesneau D, Odell, J., S. Horikawa, Kreslo, I, Lazanu, I, Pessard, H, Jipa, A., Esanu, T, Esanu, T., Campanelli, M, Virtanen, A, MAGALETTI, Lorenzo, Buizza-Avanzini M, Odell, J, Kalliokoski, T, Calviani M, Mineev, O., Valram, M, O. Bésida, Rayner, M., Haigh, M. D., Andrieu, B, Catanesi MG, Asfandiyarov, R., Franco, D., Stanca, D, Barker, GJ, Gornushkin, Y.A., Korzenev, A., Bonis, ID, G. J. Barker, Zalipska J, Calin, M, Sacco, R., E. Borriello, D. Stanca, Kawada, J, Lazanu I, Wiebusch, Christopher, T. Ariga, Bertram I, Brancus, I, Gomoiu C, C. Pistillo, Dawson, J, Bay F, Vankova-Kirilova, G., Velten, P, Berardi, V, Y. Kudenko, A. Mercadante, Murphy, S, M. Aittola, Gomoiu CM, Autiero, D, Virtanen, A., Litchfield, R.P., Di Lodovico, F, Campanelli M, Rubbia, A., Periale, Luciano, Cervera A, Mineev, O, Caretta O, T. Hasegawa, M. Quinto, Litchfield, Reuban P., Sorel, Michel, Periale, L., Maalampi J, Murdoch, M, Litchfield, RP, A. Delbart, Trzaska WH, G. Barr, De Bonis, I., Dawson J, Chesneanu, D, Zalipska, J., Levy JM, A. Vacheret, Haug S, Oprima, A., Blebea-Apostu A, Hierholzer, M., Bogomilov M, Cafagna F, F. Sato, Declais, Y, C.M. Gomoiu, Kreslo I, B. Morgan, Matveev, V, J. Dawson, Loveridge P, Chesneanu D, Hierholzer M, M.D. Haigh, Gavrilov, G, Still, B., Yu. Novikov, Morgan, B., Velotti, F, De Bonis I, Horikawa S, Gorodetzky P, Pennacchio, E., Rayner, M, A. Alekou, Przewlocki, P, A. Virtanen, De Jong, J, Galymov, V, Kawada J, Gomez J, Franco D, Rondio, E., Thompson L, Déclais, Y., Haigh M, Margineanu, R.M., L. Chaussard, Suhonen, J., Cantini, C, Wilson J, P. Del Amo Sanchez, J. Odell, Weber, A., Bandac I, M.D. Fitton, L. Epprecht, J. Suhonen, Hissa J, Kudenko Y, Blebea-Apostu, A. M., Kudryavtsev V, Ristea, O, G. Vasseur, Efthymiopoulos, I., P. Przewlocki, Nikolics, K, Brancus I, Huitu K, Mitrica B, A. Oprima, Thompson LF, Rubbia, André, Shaposhnikova, E., Gornushkin, Y. A., P. Loveridge, Levy, J. M., Korzenev A, Coleman, J, Gomoiu, CM, F. Antoniou, J. Marteau, Valram, M., E. Kokko, Banerjee, D, Haigh, MD, Tuominen K, Duchesneau, D., Catanesi, MG, L. Periale, Gendotti, Adamo, V.A. Kudryavtsev, Campanelli, M., E. Rondio, Haigh MD, M. Calin, Sarkamo, J, Nikolics K, Suhonen, J, Murdoch M, Antoniou, F., Vankova-Kirilova, G, Litchfield RP, Chaussard L, Franco, D, Bertram, I., Levy, J. -M., Duchesneau, D, B. Goddard, Buizza Avanzini, M., Ramachers Y, O’keeffe, H., Kuusiniemi, P., N. Saviano, G. Cata-Danil, Papaphilippou, Y, Huitu, K., Chipesiu, F, A. Eliseev, Ballett, P., M. Campanelli, Noah, E, J.R. Wilson, D. Sgalaberna, Berardi V, A.N. Erykalov, Blondel, A, Cafagna, F, Bandac, I., Wilson, JR, Ratoff, PN, Szeptycka, M, J.J. Gomez, Karadzhov, Y., Steerenberg, R, Emery, S, Vorobyev, A., Rubbia A, Chakraborty, S., Grant, N., Galymov V, I. Lazanu, Khotjantsev, A, Khabibullin, M, A. Vorobyev, Sergiampietri F, Ratoff, P.N., Borriello E, Sgalaberna D, Christodoulou, G, Virtanen A, Resnati, F, K. Sakashita, O'Keeffe, H., Morgan, B, Finch, Alex, Aittola, M, Morgan B, L. Magaletti, R.M. Margineanu, Chaussard, L, E. Scantamburlo, Rummukainen, K, Fitton, M. D., Dumarchez J, Antoniou, F, Lagoda J, Wark D, Kudenko, Y., Sgalaberna, D., Fitton MD, A. Weber, Kopylov, AN, Tuominen, K., Rubbia, A, Haesler A, Levy, J.-M., Robert, A., Levy, JM, Chaussard, L., Zito M, Lagoda, J., B. Andrieu, Efthymiopoulos I, Levy J, Sterian, P., Stahl A, Karadzhov, Y, Gendotti, A., Rondio E, Margineanu, R. M., Densham C, Gomez JJ, Goddard, B, Borriello, E, Kopylov A, Loveridge, P., Horikawa, S., Densham, C, Epprecht, L., Fitton, M.D., Murphy, S., Cervera, A, Mirizzi, A., Tonazzo, A., Wu, S., Kumpulainen, J., O. Mineev, Haigh, Martin David, M. Bogomilov, K. Loo, K. Mavrokoridis, Agarwalla, S.K, HASH(0x55a67fd79a80), Kormos, L. L., S. Murphy, D. Banerjee, Enqvist K, Toma G, R. Asfandiyarov, Nikolics, K., Enqvist T, J. Hissa, Kudenko, Y, M. Szeptycka, T. Patzak, Caretta, O, Izmaylov A, E. Noah, Kalliokoski T, S. Chakraborty, V. Galymov, Touramanis, C., Goddard B, Calviani, M, Steerenberg, R., V. Berardi, D. Chesneanu, Mitrica, B, M. Slupecki, E. Pennacchio, Khotjantsev, A., Saviano, N, D.A. Nesterenko, Delbart, A., S. Narita, A. Bravar, Scantamburlo, E., Eliseev, A, I. Brancus, Marteau, J., Vacheret, A., Lazanu, I., Lagoda, J, Velotti, F., Viant, T., C. Wiebusch, Popov, B., Patzak T, Aittola M, Novikov, Y, T. Strauss, N. Grant, A. Ariga, Nesterenko, DA, Jong, JD, Martin-Mari C, Sterian, A.r., Kosyanenko, S, Kuusiniemi, P, F. Vanucci, Vanucci F, Pectu, M., E. Shaposhnikova, R. Steerenberg, Velten P, Suvorov, V, Gómez Cadenas, Juan José, Sergiampietri, F, Steerenberg R, Bravar A, Haug, S, Strauss T, Mazzucato, E, Tuominen, Kimmo Ilmari, Dumarchez, J, Agarwalla, S. K., Sanchez PD, Ballett P, Gendotti A, Delbart, A, R. Sacco, F. Di Lodovico, D. Wark, K. Kainulainen, Sacco, R, Mineev O, Gorodetzky, P., Bay, Francesca, Kainulainen, K, Barker, G. J., Boyd, S., K. Enqvist, Kudryavtsev VA, A. Jipa, Viant, Thierry, McCauley N, Patzak, T., PALLADINO, VITTORIO, Margineanu, RM, D. Angus, Kudryavtsev, V.a., Bay, F, J. Kawada, Quinto M, C. Giganti, Crivelli P, Vorobyev A, Emery, S., Mazzucato E, Thompson, L.F., Patzak, T, Sterian A, Zito, M., Kormos, L.L., Touramanis, C, Khabibullin M, Sarkamo J, Sterian P, O. Ristea, Kumpulainen J, Marteau, J, D. Payne, Davenne, T., Yershov, N, Vanucci, F., Vasseur G, Haug, S., Rondio, E, Still, B, Calin, M., Agostino, L., Barr G, Saftoiu, A., Kainulainen, K., G. Toma, Gornushkin Y, Yershov, N., Hissa, J., J. Maalampi, B. Mitrica, Nguyen, K., Ilic, J, Sorel, M, Alekou A, Karadzhov Y, Sato, F, Huitu, K, Barker GJ, Velotti F, Erykalov, A.N., Mavrokoridis, K., Blondel, A., Finch, AJ, Loveridge, P, Izmaylov, A, Pennacchio, E, E. Mazzucato, Bartmann, W, Novikov Y, Cafagna, F., Delbart A, Ariga, T., P. Sterian, Sterian, A. R., Sorel, M., Wilson, J. R., Hasegawa, T, Epprecht, Lukas, Spooner, NJC, Collaboration, LAGUNALBNO, Trzaska, W. H., Bandac, I, Weber, M., Goddard, B., Chakraborty S, Bésida, O, Ilic, J., Gornushkin, YA, O’Keeffe H, Kopylov AN, Grant N, Odell J, Murphy, Sébastien, Stoica, S., Antoniou F, Saviano N, Radicioni, E, A. Stahl, Haigh, M.D., Kosyanenko, S., Giganti, C., Del Amo Sanchez P, Erykalov, AN, J. Ilic, Pessard, H., Palladino V, Suvorov V, Nesterenko, D. A., N. Yershov, Collaboration, LAGUNA-LBNO, Wark, D, A.R. Sterian, S. Boyd, Magaletti, L, Margineanu RM, Narita, S., Densham, C., Kormos, LL, Nesterenko DA, Mursula K, F. Sergiampietri, Alekou, A, Chakraborty, S, Stahl, A, Vankova Kirilova, G., McCauley, N, Tonazzo, A, Ristea, O., J. De Jong, A. Cervera, Stoica S, Nguyen, K, S. Di Luise, Martin-Mari, C, Yershov N, Ioannisian, A. N., Scantamburlo E, C. Martin-Mari, Finch, A. J., Di Luise, S, T. Viant, G. Vankova-Kirilova, H. Pessard, Slupecki M, Bésida, O., Ariga T, Ramachers, Y., Davenne T, null null, Ereditato, A., Y.A. Gornushkin, Kawada, J., Popov B, Payne, D., M. Sorel, Stanca, D., Ariga A, B. Popov, Gomez, JJ, Terri R, Przewlocki, P., Sterian, P, Ravonel, M., Finch, A.J., M. Khabibullin, Blebea-Apostu, AM, Ravonel, M, Di Luise, Silvestro, Stanca D, Cata-Danil, G, Y. Déclais, Quinto, M., Spooner NJC, F. Chipesiu, Kryn D, Barker, G.J., K. Rummukainen, Kokko E, Enqvist, K., P. Kuusiniemi, Resnati, Filippo, Agarwalla SK, A. Rubbia, F. Bay, Christodoulou, G., Andrieu B, Di Luise, S., Aittola, M., O'Keeffe, H, Murdoch, M., A. Korzenev, Banerjee, D., Chipesiu F, S. Stoica, A. Saftoiu, Blondel A, Strauss, T, Slupecki, M., Deeclais Y, Toma, G, A. Khotjantsev, Bravar, A., Blebea Apostu, A. M., T. Davenne, Vincke, H, Cata Danil, G., Gomoiu, C.M., Ratoff, P. N., Fitton, MD, Mavrokoridis, K, LAGUNA-LBNO Collaboration, J. Lagoda, Spooner, N. J. C., J. Kumpulainen, Khabibullin, M., Mursula, K., Szeptycka M, Gornushkin YA, Autiero, D., Wiebusch, C, Borriello, E., Bertram, Iain, Payne, D, Epprecht L, Weber M, Lodovico, FD, Giganti, C, Agostino L, Caretta, O., Weber A, Tsenov, R, R. Tsenov, Vacheret, A, McCauley, N., Ereditato A, Efthymiopoulos, I, Maalampi, J., S. Kosyanenko, Emery S, Calviani, M., Izmaylov, A., C. Touramanis, Noah, E., Erykalov, A. N., I. De Bonis, Pennacchio E, Sorel M, Andrieu, B., Marteau J, Oprima A, Vankova-Kirilova G, Grant, N, Sacco R, Calin M, Rayner M, Coleman J, Suvorov, V., M. Ravonel, D. Duchesneau, Ramachers, Y, Di Lodovico, F., S. Haug, A. Haesler, Sanchez, PDA, Wark, D., Y. Ramachers, Vorobyev, A, K. Nikolics, Sterian AR, L.F. Thompson, Crivelli, P, Ratoff PN, BERARDI, Vincenzo, Vasseur, G., Gavrilov G, Alekou, A., A. Izmaylov, Mursula, K, Sato, F., Dawson, J., K. Nguyen, Nesterenko, D.A., Barker, Gary John, Viant T, Ioannisian, A.N., Maalampi, J, Kosyanenko S, Stahl, A., Saftoiu A, P. Gorodetzky, Bartmann, W., Pascoli S, Weber, M, A. Blondel, Martin-Mari, C., Pascoli, S., Sterian, AR, Bay, F., Agostino, L, Khotjantsev A, Kreslo, I., Chipesiu, F., P.N. Ratoff, Pistillo, C., Weber, A, Ballett, P, Wu S, Papaphilippou, Y., Ristea O, Kryn, D., Bésida O, S. Wu, Davenne, T, Narita, S, Mazzucato, E., Shaposhnikova E, Vincke H, M. Calviani, V. Suvorov, Jipa, A, Robert A, Pectu, M, De Jong, J., Boyd, Steve B., Nguyen, Khoi N., A. Mirizzi, Ioannisian A, Vincke, H., Enqvist, T., Resnati, F., Mercadante, A, A. Robert, Ioannisian AN, Mirizzi, A, Cata-Danil G, Levy, J-M, Kormos L, Erykalov A, Periale L, Blebea-Apostu, A.M., Déclais Y, Del Amo Sanchez, P, Ariga, A., Shaposhnikova, E, Suhonen J, Banerjee D, Asfandiyarov, R, Cantini C, Papaphilippou Y, M. Pectu, Esanu T, Finch AJ, T. Kalliokoski, Gomez, J.J., Zalipska, J, Tsenov, R., D. Franco, Nguyen K, Robert, A, Hasegawa, T., Angus D, Jipa A, Narita S, Bravar, A +971 morecore +1 more sourceTranscriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel +14 morewiley +1 more sourceInteraction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen +9 morewiley +1 more sourceHiggs Discovery and the Look Elsewhere Effect [PDF]
, 2013 The discovery of the Higgs particle required a signal of five sigma significance. The rigid application of that condition is a convention that disregards more specific aspects of the given experiment.Dawid, Richardcore Search for supersymmetry at √s= 8 TeV in final states with jets and two same-sign leptons or three leptons with the ATLAS detector [PDF]
, 2014 A search for strongly produced supersymmetric particles is conducted using signatures involving multiple energetic jets and either two isolated leptons (e or μ) with the same electric charge, or at least three isolated leptons.Farrington, Sinead, Harrison, P. F., Jones, G. (Graham), Pianori, E., Jeske, C., Murray, W., Martin, T. A., HASH(0x55a67fb09ef0), Janus, M. +8 morecore +1 more sourceMagnetic guidance of charged particles
Physics Letters B, 2015 Many experiments and devices in physics use static magnetic fields to guide charged particles from a source onto a detector, and we ask the innocent question: What is the distribution of particle intensity over the detector surface? One should think that Dirk Dubbersdoaj +1 more sourceInterpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo +7 morewiley +1 more source