Results 101 to 110 of about 169,131 (312)

Design and Test of Principle Prototype of Space Single Event Upset Discriminating and Positioning System

open access: yesYuanzineng kexue jishu, 2022
Single event upset (SEU) has always been an important factor affecting the reliability of spacecraft electronic equipment, which can cause anomalies in electronic equipment in orbit, and can result in serious spacecraft failure. In order to master signal
ZHAO Zhendong;TAO Wenze;LI Yancun;CHENG Yi;ZHANG Qingxiang;AN Heng;QUAN Xiaoping;ZHANG Chenguang
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

The mass-hierarchy and CP-violation discovery reach of the LBNO long-baseline neutrino experiment [PDF]

open access: yes, 2013
The next generation neutrino observatory proposed by the LBNO collaboration will address fundamental questions in particle and astroparticle physics.
Gavrilov, G.   +971 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Measuring charged current neutrino interactions in the electromagnetic calorimeters of the ND280 detector [PDF]

open access: yes, 2013
This thesis presents a study of neutrino interactions within the electromagnetic calorimeters (ECals) of the Tokai-to-Kamioka (T2K) off -axis near detector (ND280), using data collected from T2K Run II and Run III.
Scott, Mark Andrew
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Higgs Discovery and the Look Elsewhere Effect [PDF]

open access: yes, 2013
The discovery of the Higgs particle required a signal of five sigma significance. The rigid application of that condition is a convention that disregards more specific aspects of the given experiment.
Dawid, Richard
core  

Search for supersymmetry at √s= 8 TeV in final states with jets and two same-sign leptons or three leptons with the ATLAS detector [PDF]

open access: yes, 2014
A search for strongly produced supersymmetric particles is conducted using signatures involving multiple energetic jets and either two isolated leptons (e or μ) with the same electric charge, or at least three isolated leptons.
Farrington, Sinead   +8 more
core   +1 more source

Magnetic guidance of charged particles

open access: yesPhysics Letters B, 2015
Many experiments and devices in physics use static magnetic fields to guide charged particles from a source onto a detector, and we ask the innocent question: What is the distribution of particle intensity over the detector surface? One should think that
Dirk Dubbers
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

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