Results 81 to 90 of about 64,617 (266)

Flat Spectra of Energetic Particles in Interplanetary Shock Precursors

The Astrophysical Journal
The observed energy spectra of accelerated particles at interplanetary shocks often do not match the diffusive shock acceleration (DSA) theory predictions. In some cases, the particle flux forms a plateau over a wide range of energies, extending upstream
Mikhail Malkov, Joe Giacalone, Fan Guo
doaj   +1 more source

Beam Shaping Assembly Optimization for Boron Neutron Capture Therapy Facility based on Cyclotron 30 MeV as Neutron Source

ASEAN Journal on Science and Technology for Development, 2018
A design of beam shaping assembly (BSA) installed on cyclotron 30 MeV model neutron source for boron neutron capture therapy (BNCT) has been optimized using simulator software of Monte Carlo N-Particle Extended (MCNPX).
Arief Fauzi, Afifah Hana Tsurayya, Ahmad Faisal Harish, Gede Sutresna Wijaya   +3 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Bohm criterion and plasma particle/power exhaust to and recycling at the wall

Nuclear Materials and Energy, 2017
The plasma particle and power exhaust to the divertor surface drives both particle and power recycling at the surface, which in return constrains the plasma density and temperature at the target and their profile further upstream. Both particle and power
Xian-Zhu Tang, Zehua Guo
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

On the initiation of lightning in thunderclouds

Scientific Reports, 2017
The relationship of lightning and elementary particle fluxes in the thunderclouds is not fully understood to date. Using the particle beams (the so-called Thunderstorm Ground Enhancements – TGEs) as a probe we investigate the characteristics of the ...
Ashot Chilingarian, Suren Chilingaryan, Tigran Karapetyan, Lev Kozliner, Yeghia Khanikyants, Gagik Hovsepyan, David Pokhsraryan, Suren Soghomonyan   +7 more
doaj   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Particle transport in reduced turbulence neutral beam heated discharges at Wendelstein 7-X

Nuclear Fusion
A spontaneous reduction in anomalous particle transport in the plasma core is seen experimentally in reproducible, purely neutral beam heated plasma phases at Wendelstein 7-X (W7-X).
S. Bannmann, O. Ford, P.Zs. Poloskei, J. Svensson, A. Pavone, S. Kwak, U. Hoefel, E. Pasch, G. Fuchert, H.M. Smith, S. Lazerson, P. McNeely, N. Rust, D. Hartmann, R.C. Wolf, the W7-X Team   +15 more
doaj   +1 more source

On the assessment of sinking particle fluxes from in situ particle size distributions

Journal of Geophysical Research: Biogeosciences
The biological carbon pump is a vital component of the global carbon cycle, particularly through sinking of particulate organic carbon (POC) to the ocean interior. Particle size distribution (PSD) observations from the Underwater Vision Profiler (UVP) have been widely used to quantify sinking POC fluxes.
Elena Ceballos Romero, Ken Buesseler, Erik Fields, Rainer Kiko, Meg Estapa, Lee Karp‐Boss, Samantha Clevenger, Laetitia Drago, David A. Siegel   +8 more
openaire   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source