Results 141 to 150 of about 43,251,177 (344)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Two-layer particle filter for multiple target detection and tracking [PDF]
, 2012 This paper deals with the detection and tracking of an unknown number of targets using a Bayesian hierarchical model with target labels. To approximate the posterior probability density function, we develop a two-layer particle filter.
Morelande, Mark R. +2 more
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
A Language Model for Particle Tracking
CoRRParticle tracking is crucial for almost all physics analysis programs at the Large Hadron Collider. Deep learning models are pervasively used in particle tracking related tasks. However, the current practice is to design and train one deep learning model for one task with supervised learning techniques.
Andris Huang +6 more
openaire +3 more sources
Microscale Modeling of Frozen Particle Fluid Systems with a Bonded-Particle Model Method. [PDF]
Materials (Basel), 2022 Chan TT, Heinrich S, Grabe J, Dosta M.
europepmc +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Balanced Standing on One Foot of Biped Robot Based on Three-Particle Model Predictive Control. [PDF]
Biomimetics (Basel), 2022 Yang Y +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
The Phase Field Model of the Insoluble Particle–Interface Interaction During Solidification
MetalsIn this work, the phase field model was developed to understand the redistribution behavior of insoluble particles during metal solidification. This was achieved by modifying the pure solidification model to incorporate the insoluble particle using an ...
Simbarashe Fashu +2 more
doaj +1 more source
Numerical Modeling of Fixed-Bed Cocombustion Processes through the Multiple Thermally Thick Particle Model. [PDF]
ACS Omega, 2022 Deng R, Wang L, Zhang R, Luo Y.
europepmc +1 more source