Results 151 to 160 of about 43,251,177 (344)
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
RG203KR Mutations in SARS-CoV-2 Nucleocapsid: Assessing the Impact Using a Virus-Like Particle Model System. [PDF]
Microbiol Spectr, 2022 Raheja H +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
A New Motion Model Selection Approach for Multi-Model Particle Filters [PDF]
Radioengineering, 2019 One of the important factors in real-time tracking of the moving radar targets is the speed of the algorithm. In the multi-model particle filters (MMPFs) which is frequently preferred tracking of such targets, the numbers of particles and motion models ...
M. B. Ucar, D. Yilmaz
doaj
Discrete-Particle Model to Optimize Operational Conditions of Proton-Exchange Membrane Fuel-Cell Gas Channels. [PDF]
ACS Appl Energy Mater, 2021 Niblett D, Holmes SM, Niasar V.
europepmc +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Numerical Optimization for the Geometric Configuration of Ceramics Perform in HCCI/ZTAP Wear-Resistant Composites Based on Actual Particle Model. [PDF]
Nanoscale Res Lett, 2021 Xu R +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Extended Particle Model of Elementary Particles [PDF]
Progress of Theoretical Physics Supplement, 1968 Osamu Hara, Tetsuo Gotō
openaire +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source