Results 211 to 220 of about 43,251,177 (344)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Formations of force network and softening of amorphous elastic materials from a coarsen-grained particle model. [PDF]

Sci Rep
Kurita R, Tamura Y, Tani M.
europepmc   +1 more source

Discrete particle model for cement infiltration within open-cell structures: Prevention of osteoporotic fracture. [PDF]

PLoS One, 2018
Ramos-Infante SJ, Ten-Esteve A, Alberich-Bayarri A, Pérez MA.   +3 more
europepmc   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Electrophysical cardiac remodeling at the molecular level: Insights into ryanodine receptor activation and calcium-induced calcium release from a stochastic explicit-particle model. [PDF]

Biophys J
Hirakis SP, Bartol TM, Autin L, Amaro RE, Sejnowski TJ.   +4 more
europepmc   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Random non-convex particle model for the fraction of interfacial transition zones (ITZs) in fully-graded concrete

, 2018
Wen-Xiang Xu, Zhong-Mei Han, L. Tao, Qi-Han Ding, Huai-Fa Ma   +4 more
semanticscholar   +1 more source

Effect of thermal treatment on microcracking characteristics of granite under tensile condition based on bonded-particle model and moment tensor. [PDF]

Sci Rep
Zhao J, Sun W, Luo H, Wu S, Hou Z.
europepmc   +1 more source

Prediction of thermal distribution and fluid flow in the domain with multi-solid structures using Cubic-Interpolated Pseudo-Particle model.

PLoS One, 2020
Nguyen Q, Babanezhad M, Taghvaie Nakhjiri A, Rezakazemi M, Shirazian S.   +4 more
europepmc   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source