Results 41 to 50 of about 544,299 (268)

Molecular modeling of the chromatosome particle [PDF]

Nucleic Acids Research, 2003
In an effort to understand the role of the linker histone in chromatin folding, its structure and location in the nucleosome has been studied by molecular modeling methods. The structure of the globular domain of the rat histone H1d, a highly conserved part of the linker histone, built by homology modeling methods, revealed a three-helical bundle fold ...
Bharath, Srinivas MM, Chandra, Nagasuma R, Rao, MRS   +2 more
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A particle-core model for inhomogeneous and mismatched charged particle beams

AIP Advances, 2017
This work presents a particle-core model for an inhomogeneous and mismatched nonneutral charged particle beam. The beam is azimuthally symmetric, initially cold, and is confined by an external constant magnetic field inside a cylindrical conducting pipe.
R. P. Nunes
doaj   +1 more source

A particle model of the Stefan problem [PDF]

Computer Methods in Applied Mechanics and Engineering, 1978
Abstract The melting of triangular and rectangular solids is analyzed by means of new particle-type models. Heating is defined in terms of the increase of a particle's velocity, while temperature is defined in terms of a particle's kinetic energy. Computer examples are given of slow heating, fast heating, heating from above and heating from below. In
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Modeling and experimental analysis of particle damping phononic crystal plate

AIP Advances, 2021
A phononic crystal with particle assembly dampers was constructed. A high-speed camera was used to record and observe the vibration phenomenon of the particle assembly under external excitation.
Yuanchao Zhang, Wei Xu, Chiming Wang, Zhengmin Li, Jianwei Cheng, Shengwu Zhang   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A stringy model of pointlike particles

Nuclear Physics B, 2022
A previous supersymmetric preon scenario for visible matter particles is extended to the dark sector. In addition, the scenario is reformulated as a Double Field Theory (DFT) with four extra dimensions, to avoid a singular Big Bang in cosmology. T-duality and doubled local Lorentz symmetry of the model are genuine stringy properties.
openaire   +4 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Numerical Modeling of Reinforcement Solutions in Traditional Stone Masonry Using a Particle Model

Buildings
Traditional stone masonry walls are structural elements in most historic buildings. To preserve them and improve their ability to withstand extreme events, such as earthquakes, it is necessary to implement effective reinforcement solutions.
Nuno Monteiro Azevedo, Ildi Cismaşiu, Fernando F. S. Pinho, Filipe Neves   +3 more
doaj   +1 more source