Results 31 to 40 of about 1,035,649 (177)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Particle Physics in the Cosmos [PDF]

Proceedings of Neutrino Oscillation Workshop — PoS(NOW2016), 2017
The Session V “Particles in the Cosmos”, at the NOW 2016 workshop, is dedicated to the interplay among the theory and phenomenology of particle physics theories and cosmological models. The main topics faced during the sessions were addressed to the cosmological implications of the neutrinos and of other possible extra species in the Universe, and to ...
Franco, Davide, Saviano, Ninetta
openaire   +3 more sources

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Particle Physics and Cosmology [PDF]

, 2002
In this talk I review the present status of inflationary cosmology and its emergence as the basic paradigm behind the Standard Cosmological Model, with parameters determined today at better than 10% level from CMB and LSS observations.Comment: 12 pages ...
Garcia-Bellido, Juan
core   +1 more source

Review of Particle Physics [PDF]

, 1998
The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 2,143 new measurements from 709 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons.
Caso, C, Conforto, G, Gurtu, A, Aguilar-Benitez, M, Amsler, C, Barnett, RM, Burchat, PR, Carone, CD, Dahl, O, Doser, M, Eidelman, S, Feng, JL, Goodman, M, Grab, C, Groom, DE, Hagiwara, K, Hayes, KG, Hernandez, JJ, Hikasa, K, Honscheid, K, James, F, Mangano, ML, Manohar, AV, Monig, K, Murayama, H, Nakamura, K, Olive, KA, Piepke, A, Roos, M, Schindler, RH, Shrock, RE, Tanabashi, M, Tornqvist, NA, Trippe, TG, Vogel, P, Wohl, CG, Workman, RL, Yao, WM, Armstrong, B, Casas Serradilla, JL, Filimonov, BB, Gee, PS, Lugovsky, SB, Mankov, S, Nicholson, F, Babu, KS, Besson, D, Biebel, O, Cahn, RN, Crawford, RL, Dalitz, RH, Damour, T, Desler, K, Donahue, RJ, Edwards, DA, Erler, J, Ezhela, VV, Fasso, A, Fetscher, W, Froidevaux, D, Gaisser, TK, Garren, L, Geer, S, Gerber, HJ, Gilman, FJ, Haber, HE, Hagmann, C, Hinchliffe, I, Hogan, CJ, Hohler, G, Jackson, JD, Johnson, KF, Karlen, D, Kayser, B, Kleinknecht, K, Knowles, IG, Kolda, C, Kreitz, P, Langacker, P, Landua, R, Littenberg, L, Manley, DM, March-Russell, J, Nakada, T, Quinn, H, Raffelt, G, Renk, B, Ronan, MT, Rosenberg, LJ, Schmitt, M, Schramm, DN, Scott, D, Sjostrand, T, Smoot, GF, Spanier, S, Srednicki, M, Stanev, T, Suzuki, T, Tkachenko, NP, Valencia, G   +99 more
openaire   +6 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Intersections 2000: What's New in Hadron Physics

, 2000
Hadron physics is that part of QCD dealing with hadron structure and vacuum structure, almost all of which is nonperturbative in nature. Some of the open problems in this field are outlined.
Bjorken, J. D.
core   +1 more source

Particle Accelerator Physics [PDF]

, 1993
This book by Helmut Wiedemann is a well-established, classic text, providing an in-depth and comprehensive introduction to the field of high-energy particle acceleration and beam dynamics. The present 4th edition has been significantly revised, updated and expanded.
openaire   +3 more sources

An approach for coherent periodogram averaging of tilt‐series data for improved contrast transfer function estimation

FEBS Open Bio, EarlyView.
The contrast transfer function (CTF) is an imaging aberration that is a major resolution‐limiting factor in cryo‐electron microscopy (cryo‐EM). Precise CTF estimation is key to overcoming this limitation, but is particularly challenging in cryo‐electron tomography (cryo‐ET) data. Here, we present an approach for using geometric information to assist in
Sagar Khavnekar, William Wan
wiley   +1 more source