Results 61 to 70 of about 1,266,580 (282)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tetraquarks at large M and large N

Journal of High Energy Physics
We study tetraquarks in large N QCD with heavy quarks, in the domain where non-relativistic quantum mechanics offers an adequate approximation. Within the regime of validity of the Born-Oppenheimer approximation, we systematically study and explicitly ...
Héloïse Allaman, Majid Ekhterachian, Filippo Nardi, Riccardo Rattazzi, Stefan Stelzl   +4 more
doaj   +1 more source

Geometry of particle physics [PDF]

Advances in Theoretical and Mathematical Physics, 2009
43 pages, 19 figures, latex; v2: orientifold projection in section 5.1 corrected, further minor ...
openaire   +5 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Teaching particle physics to high school teachers

, 2017
In Norway, particle physics is part of the high school curriculum in physics which introduces the need for good university teaching in particle physics without the usual technical approach.
Bomark, Nils-Erik
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Particle Physics with ORCA [PDF]

EPJ Web of Conferences, 2019
KM3NeT is a Megaton-scale neutrino telescope currently under construction at the bottom of the Mediterranean Sea. When completed, it will consist of two separate detectors: ARCA (Astroparticle Research with Cosmics in the Abyss), optimised for high ...
Domi Alba, Bourret Simon, Quinn Liam
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Cosmic Physics: The High Energy Frontier

, 2003
Cosmic rays have been observed up to energies $10^8$ times larger than those of the best particle accelerators. Studies of astrophysical particles (hadrons, neutrinos and photons) at their highest observed energies have implications for fundamental ...
Abu-Zayyad T, Abu-Zayyad T, Aharonian F, Aharonian F A, Aharonian F A, Aharonian F A, Ahmad Q R, Ahn E-J, Alavi-Harati A, Albuquerque I F M, Alfaro J, Alfaro J, Alfaro J, Allen S W, Aloisio R, Alvarez-M?niz J, Amelino-Camilia G, Anchordoqui L A, Anchordoqui L A, Anchordoqui L A, Arkani-Hamed N, Atkins R, Ave M, Ave M, Baade W, Bandyopadhyay A, Barbot C, Berezinsky V, Berezinsky V S, Berezunsky V S, Bershady M A, Bhattacharjee P, Bhattacharjee P, Bhattacharyya G, Biermann P L, Biermann P L, Biller S, Biller S, Bird D J, Bird D J, Blanton M, Blasi P, Bloom E D, Boldt E, Boldt E, Bordes J, Brown R W, Bulik T, Burdman G, Butt Y M, Catanese M, Catanese M, Chadwick P M, Cheng K S, Cheung D J H, Chisholm J R, Cillis A N, Cline D, Coleman S, Colladay D, Colles M, Dai, Daugerty J K, De Jager O C, De Marco D, Dicus D A, Dimopoulos S, Domokos G, Domokos G, Domokos G, Drury L, Drury L, Dwek E, Dwek E, Dwek E, Elbaz D, Elbert J W, Elgaroy, Ellis J, Ellis J, Ellis J, Engel R, Enomomto R, Erber T, F W Stecker, Falcke H, Fall S M, Fargion D, Farrar G R, Farrar G R, Feng J L, Fixsen D J, Fixsen D J, Fossati G, Fukuda Y, Fukuda Y, Gaisser T K, Gaisser T K, Gandhi R, Garay L J, Gelmini G, Georgi H, Ginzburg V L, Gispert R, Glashow S L, Gould R J, Greisen K, Guy J, Halzen F, Halzen F, Hartman R C, Hauser M G, Hauser M G, Hayashida N, Hill C T, Hillas A M, Hurley K, Jacobson T, Jacobson T, Jain P, Jones T W, Jorstad S G, Kachelrieß M, Kaluza T, Kazanas D, Kibble T W B, Kifune T, Kifune T, Klein O, Kolb E W, Konopelko A K, Konopka T, Krawczynski, Krennrich F, Krennrich F, Krizmanic J F, Krolik J, Kulkarni S R, Kuo C I, Kusenko A, Kuz'min V A, Lagache G, Landau L D, Learned J G, Lilly S J, Linsley J, Livio M, Madau P, Madau P, Malkan M A, Malkan M A, Mannheim K, Mao S, Mastichiadas A, Mather J, Michelson P F, Migdal A B, Muraishi H, Myers C, Mészáros P, Nagano M, Nishimura J, Norris J, Nussinov S, Olinto A, Pearson T J, Penzias A A, Petry D, Petry D, Pettini M, Pian E, Pohl M, Protheroe R J, Puget J-L, Puget J-L, Punch M, Pühlhofer G, Quinn J, Randall L, Robinett R W, Rowan-Robinson M, Salam A, Salamon M H, Sarkar S, Sasaki N, Sato H, Schaefer B E, Schaefer B E, Schmidt M, Schmidt M, Scully S T, Shinozaki K, Shklovskii I S, Sigl G, Smalin L, Smoot G, Smy M B, Sokolsky P, Spergel D N, Sreekumar P, Stanev T, Stanev T, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Stecker F W, Steidel C C, Takeda M, Takeda M, Takeda M, Tan J C, Tanimori T, Tanimori T, Tremaine S, Tyler C, Vietri M, Vietri M, Waxman E, Waxman E, Wdowczyk J, Weekes T C, Weiler T J, Weiler T J, Weinberg S, Weinberg S, Weinheimer C, Wischnewski R, Wright E L, Xu C, Yoshida S, Yoshikoshi T, Zas E, Zatsepin G T   +251 more
core   +1 more source