Results 131 to 140 of about 3,316,013 (300)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
BuildingsThe maximum shear modulus (Gmax) of soils is a critical parameter in geotechnical design and advanced constitutive modeling. While the effects of fines content (FC) and particle shape on Gmax have been studied extensively, their collective influence on ...
Yuyang Tian +3 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Experimental study on influence of particle shape on shockwave from collapse of cavitation bubble. [PDF]
Ultrason Sonochem, 2023 Zou L +6 more
europepmc +1 more source
Shape-Anisotropic Diblock Copolymer Particles from Evaporative Emulsions: Experiment and Theory
, 2019 Self-assembly of block copolymers (BCPs) in evaporative emulsion provides a simple and effective route for the preparation of anisotropic particles with controlled shape and size.
Bumjoon J. Kim (1477771) +7 more
core +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Applied SciencesThis study posits that soil particles in the filter layer are ellipsoidal. The effective pore radius of the filter material was calculated for various particle-shape parameters and distributions.
Wei-Kang Bai +5 more
doaj +1 more source
Data for: "The Effect of Particle Shape on their Trajectories in Particle Laden Flows"
This dataset contains the scanning electron microscope (SEM) images that are used for the particle shape analysis. The images are generated with the TESCAN Vega3 microscope. The uploaded images are the raw images. Three sample holders are scanned.
Staudacher, Stephan, Hartmann, Jan
core +1 more source