Results 71 to 80 of about 3,024,720 (334)

Particle Shape Effect on Macroscopic Behaviour of Underground Structures: Numerical and Experimental Study

open access: yesStudia Geotechnica et Mechanica, 2015
The mechanical performance of underground flexible structures such as buried pipes or culverts made of plastics depend not only on the properties of the structure, but also on the material surrounding it.
Szarf Krzysztof   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A Study on Shape-Dependent Settling of Single Particles with Equal Volume Using Surface Resolved Simulations

open access: yesComputation, 2021
A detailed knowledge of the influence of a particle’s shape on its settling behavior is useful for the prediction and design of separation processes. Models in the available literature usually fit a given function to experimental data.
Robin Trunk   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Shape Machine and Interpreters

open access: yes, 2019
Presented as part of the Shape Machine Symposium on April 11, 2019 at 10:34 a.m. in the John & Joyce Caddell Building, Flex Space.Tzu-Chieh Kurt Hong is a PhD candidate in the School of Architecture at the Georgia Institute of Technology.
Hong, Tzu-Chieh Kurt
core   +1 more source

On-line learning of shape information for object segmentation and tracking [PDF]

open access: yes, 2009
We present segmentation and tracking of deformable objects using non-linear on-line learning of high-level shape information in the form of a level set function.
Chiverton, John   +7 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Numerical investigation of motion of a non-spherical particle (Effects of gas blowing-out on motion of a particle in a uniform flow)

open access: yesNihon Kikai Gakkai ronbunshu, 2015
This paper reports a numerical investigation of the motion of spherical and non-spherical particles with/without gas blowing-out in a vertical uniform flow. A sphere, spheroid and pulverized coal particle are targeted in this study.
Wei ZHANG   +4 more
doaj   +1 more source

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