Results 111 to 120 of about 3,016,111 (298)

Shape-directed rotation of homogeneous micromotors via catalytic self-electrophoresis

Nature Communications, 2019
The pursuit of chemically-powered colloidal machines requires individual components that perform different motions within a common environment. Such motions can be tailored by controlling the shape and/or composition of catalytic microparticles; however,
Ada M. Brooks, Mykola Tasinkevych, Syeda Sabrina, Darrell Velegol, Ayusman Sen, Kyle J. M. Bishop   +5 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Transforming Mesoscale Granular Plasticity Through Particle Shape

Physical Review X, 2019
When an amorphous material is strained beyond the point of yielding, it enters a state of continual reconfiguration via dissipative, avalanchelike slip events that relieve built-up local stress.
Kieran A. Murphy, Karin A. Dahmen, Heinrich M. Jaeger   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Lunar regolith simulations with discrete element method based on Chang'E-5 mission's lunar soil particle morphology

Yantu gongcheng xuebao
To align with the current strategic planning of "survey, mining, and development" in China's lunar exploration mission, and to obtain more accurate physical and mechanical properties of lunar regolith, this study focuses on the influences of lunar ...
WANG Siyuan 1, , JIANG Mingjing 2, 3, 4
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Individual Particle Motion in Colloids: Microviscosity, Microdiffusivity, and Normal Stresses [PDF]

, 2011
Colloidal dispersions play an important role in nearly every aspect of life, from paint to biofuels to nano-therapeutics. In the study of these so-called complex fluids, a connection is sought between macroscopic material properties and the micromechanics
Zia, Roseanna Nellie
core   +1 more source

Shape of Small Particles [PDF]

Nature, 1964
I REGRET that the index 2 was omitted from one of the β's in the denominator of equation (19) in my article published in Nature under the above title1; this was due to an error in the analysis which escaped me and was later detected by Mr. J. Cartwright of the Safety in Mines Research Establishment when applying the method to coal dust.
openaire   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source