Results 131 to 140 of about 3,016,111 (298)
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Interactive Introduction to Shape Machine
, 2019 Presented as part of the Shape Machine Symposium on April 11, 2019 at 9:10 a.m. in the John & Joyce Caddell Building, Flex Space.Athanassios (Thanos) Economou is Professor in the College of Design at Georgia Institute of Technology.
Economou, Athanassios +1 more
core
Experimental study on influence of particle shape on shockwave from collapse of cavitation bubble. [PDF]
Ultrason Sonochem, 2023 Zou L +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Abradable DEM: A Novel Framework to Capture the Mechanistic Evolution of Particle Shape
Although various methods exist for modelling non-spherical particles in DEM, particles’ shapes are usually treated as immutable. However, particles often change shape gradually, e.g., due to abrasion or accrued plastic deformation.
Rogan, Haydn
core +1 more source
Calculating Shape Factors from Particle Sizing Data
, 1996 It is well established that particle size and shape substantially influence the bulk properties of powdered materials. Although these characteristics are closely interrelated, the tendency has been to analyse the particle size independently from particle
Barreiros, Fátima M. +5 more
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Wrapping anisotropic microgel particles in lipid membranes: Effects of particle shape and membrane rigidity. [PDF]
Proc Natl Acad Sci U S A, 2023 Liu X +8 more
europepmc +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
The Effect of Particle Shape on the Compaction of Realistic Non-Spherical Particles-A Multi-Contact DEM Study. [PDF]
Pharmaceutics, 2023 Giannis K, Kwade A, Finke JH, Schilde C.
europepmc +1 more source