Results 51 to 60 of about 5,905,435 (301)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Combining experiment and prediction to explore surface chemistry and dissolution
IUCrJA crystal structure is often an integral component in the development of a new pharmaceutical product, and these structures are frequently used to understand, assess and often predict both the manufacturing and in vivo behaviour of these compounds ...
Andrew G. P. Maloney
doaj +1 more source
Performance Parameters and Characterizations of Nanocrystals: A Brief Review
Pharmaceutics, 2016 Poor bioavailability of drugs associated with their poor solubility limits the clinical effectiveness of almost 40% of the newly discovered drug moieties.
Manasi M. Chogale +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Applied SciencesParticle shape is a critical factor governing the macroscopic behavior of granular materials. While the Discrete Element Method (DEM) has proven to be a powerful tool for modeling these materials, the accurate representation of particles with realistic ...
Pei Zhang +5 more
doaj +1 more source
Studia Geotechnica et Mechanica, 2015 The mechanical performance of underground flexible structures such as buried pipes or culverts made of plastics depend not only on the properties of the structure, but also on the material surrounding it.
Szarf Krzysztof +2 more
doaj +1 more source
DEM analysis of the effect of particle shape, cohesion and strain rate on powder rheometry
Powder Technology, 2019 Discrete Element Method (DEM) is used to simulate the flow of particles addressing the influence of shear strain rate, particle shape and cohesion on the flow characteristics.
V. Vivacqua +3 more
semanticscholar +1 more source
Nihon Kikai Gakkai ronbunshu, 2015 This paper reports a numerical investigation of the motion of spherical and non-spherical particles with/without gas blowing-out in a vertical uniform flow. A sphere, spheroid and pulverized coal particle are targeted in this study.
Wei ZHANG +4 more
doaj +1 more source