Results 131 to 140 of about 6,010,535 (335)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Wrapping anisotropic microgel particles in lipid membranes: Effects of particle shape and membrane rigidity. [PDF]

open access: yesProc Natl Acad Sci U S A, 2023
Liu X   +8 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

open access: yesFEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Particle Shape-Driven Stiffness Anisotropy in Calcareous Sand and the Underlying Mechanism

open access: yesApplied Sciences
The angular shape and breakage of particles for calcareous sand significantly influence its mechanical behavior and the safety of the engineering. Although previous studies have explored the impact of particle shape on the mechanical properties of ...
Yan Gao   +4 more
doaj   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

open access: yesFEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq   +3 more
wiley   +1 more source

Influence of Fines Content and Particle Shape on Limiting Void Ratios of Sand Mixtures: DEM and AI Approaches

open access: yesBuildings
The mechanical behavior of sand–fines mixtures is governed by their limiting void ratios, which are sensitive to fines content and particle morphology. Conventional empirical correlations often fail to generalize to a wide range of soils, limiting their ...
Weichao Tang   +4 more
doaj   +1 more source

Impact of Particle Shape and Surface Group on Membrane Fouling. [PDF]

open access: yesMembranes (Basel), 2022
Tanis-Kanbur MB   +3 more
europepmc   +1 more source

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