Results 141 to 150 of about 6,010,535 (335)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Effect of the particle shape on the shear mechanical behavior of coral sand

Materials Research Express
Coral sand particles exhibit a wide range of shapes, which can be divided into four shapes, e.g., blocky, dendritic and rodlike, flaky, and shell debris. The particle shape of these mixtures is defined by the sphericity, concavity, aspect ratio, flatness
Xin Zhang, Linjian Ma, Jiewei Ke, Zhiqiang Yan, Zheyan Feng, Limingxin Zong   +5 more
doaj   +1 more source

Assembling Biocompatible Polymers on Gold Nanoparticles: Toward a Rational Design of Particle Shape by Molecular Dynamics. [PDF]

ACS Omega, 2022
Cappabianca R, De Angelis P, Cardellini A, Chiavazzo E, Asinari P.   +4 more
europepmc   +1 more source

Ceramic powder for sintering materials [PDF]

Surface activity of ceramic powders such as MgO and Al2O3, for use in sintering with sp. emphasis on their particle size, shape, particle size distribution, packing, and coexisting additives and impurities are ...
Akiya, H., Saito, A.
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Lunar regolith simulations with discrete element method based on Chang'E-5 mission's lunar soil particle morphology

Yantu gongcheng xuebao
To align with the current strategic planning of "survey, mining, and development" in China's lunar exploration mission, and to obtain more accurate physical and mechanical properties of lunar regolith, this study focuses on the influences of lunar ...
WANG Siyuan 1, , JIANG Mingjing 2, 3, 4
doaj   +1 more source

Efficient solution of particle shape functions for the analysis of powder total scattering data. [PDF]

J Appl Crystallogr, 2022
Leonardi A, Neder R, Engel M.
europepmc   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Synthesis of Hydrophobic Nanosized Silicon Dioxide with a Spherical Particle Shape and Its Application in Fire-Extinguishing Powder Compositions Based on Struvite. [PDF]

Nanomaterials (Basel), 2023
Valtsifer IV, Huo Y, Zamashchikov VV, Shamsutdinov AS, Kondrashova NB, Sivtseva AV, Pyankova AV, Valtsifer VA.   +7 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source