Results 91 to 100 of about 18,366,547 (391)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Quark transverse spin-momentum correlation of the nucleon from lattice QCD: the Boer-Mulders function

Journal of High Energy Physics
We present the first lattice QCD calculation of the quark transverse spin-momentum correlation, i.e., the naive time-reversal-odd Boer-Mulders function, of the nucleon, using large-momentum effective theory (LaMET).
The Lattice Parton collaboration, Lingquan Ma, Jun Hua, Andreas Schäfer, Hai-Tao Shu, Yushan Su, Peng Sun, Lisa Walter, Wei Wang, Xiaonu Xiong, Yi-Bo Yang, Jian-Hui Zhang, Qi-An Zhang   +12 more
doaj   +1 more source

Defect structures and torque on an elongated colloidal particle immersed in a liquid crystal host

, 2002
Combining molecular dynamics and Monte Carlo simulation we study defect structures around an elongated colloidal particle embedded in a nematic liquid crystal host.
A. Borštnik, A. Borštnik, A. Sonnet, B.I. Lev, B.J. Berne, D. Andrienko, Denis Andrienko, E. Berggren, F. Brochard, F.N. Braun, Gregor Skačej, H. Stark, H. Stark, J.A. Barker, J.C. Loudet, J.G. Gay, J.L. Billeter, M. Stephen, Michael P. Allen, N. Metropolis, N. Priezjev, N. Schopohl, O. Mondain-Monval, O.V. Kuksenok, P. Poulin, P. Poulin, P.A. Lebwohl, R.W. Ruhwandl, S.P. Meeker, S.V. Burylov, S.V. Shiyanovskii, Slobodan Žumer, T.C. Lubensky, U. Fabbri, V.J. Anderson, V.J. Anderson, Y. Gu   +36 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Single-particle cryo-EM at atomic resolution

Nature, 2020
The three-dimensional positions of atoms in protein molecules define their structure and their roles in biological processes. The more precisely atomic coordinates are determined, the more chemical information can be derived and the more mechanistic ...
T. Nakane, A. Kotecha, A. Sente, G. McMullan, S. Masiulis, P.M.G.E. Brown, I. Grigoras, L. Malinauskaite, T. Malinauskas, J. Miehling, Lingbo Yu, D. Karia, E. Pechnikova, Erwin de Jong, J. Keizer, M. Bischoff, J. McCormack, P. Tiemeijer, S. Hardwick, D. Chirgadze, G. Murshudov, A. Aricescu, S. Scheres   +22 more
semanticscholar   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Crystalizing the Spinon Basis [PDF]

, 1995
The quasi-particle structure of the higher spin XXZ model is studied. We obtained a new description of crystals associated with the level $k$ integrable highest weight $U_q(\widehat{sl_2})$ modules in terms of the creation operators at $q=0$ (the ...
A. Tsuchiya, A.N. Kirillov, Atsushi Nakayashiki, B. Davies, D. Bernard, E. Date, F. Haldane, F. Smirnov, G. Andrews, I.B. Frenkel, K. Miki, L. Faddeev, L. Takhatajan, M. Idzumi, M. Jimbo, M. Jimbo, M. Kashiwara, M. Kashiwara, M. Kashiwara, N. Reshetikhin, P. Bouwknegt, S-J. Kang, Yasuhiko Yamada   +22 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Experimental Study on the Damping Effect of Multi-Unit Particle Dampers Applied to Bracket Structure

Applied Sciences, 2019
Particle damping (PD) is a passive mean of vibration control in which small metallic or ceramic particles are placed inside a cavity that attached to the primary structure at the place of high vibration amplitudes.
Hang Ye, Yanrong Wang, Bin Liu, Xianghua Jiang   +3 more
doaj   +1 more source

Colloquium: Status of α -particle condensate structure of the Hoyle state [PDF]

, 2017
The present understanding of the structure of the Hoyle state in 12C is reviewed. Most of the theoretical approaches to the Hoyle state are shortly summarized. The corresponding results are analyzed with respect to whether they give evidence to the alpha
A. Tohsaki, H. Horiuchi, P. Schuck, G. Roepke   +3 more
semanticscholar   +1 more source