Results 81 to 90 of about 240,027 (317)

The International Linear Collider

, 2013
In this article, we describe the key features of the recently completed technical design for the International Linear Collider (ILC), a 200-500 GeV linear electron-positron collider (expandable to 1 TeV) that is based on 1.3 GHz superconducting radio ...
Barish, Barry, Brau, James E.
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Development of Ultra-Fast Silicon Detectors for 4D tracking

Nuclear Instruments and Methods in Physics Research Section A : Accelerators, Spectrometers, Detectors and Associated Equipment, 2017
In this contribution we review the progress towards the development of a novel type of silicon detectors suited for tracking with a picosecond timing resolution, the so called Ultra-Fast Silicon Detectors.
A. Staiano, R. Arcidiacono, M. Boscardin, G. Betta, N. Cartiglia, F. Cenna, M. Ferrero, F. Ficorella, M. Mandurrino, M. Obertino, L. Pancheri, G. Paternoster, V. Sola   +12 more
semanticscholar   +1 more source

Jitter Measurements of 1 cm² LGADs for Space Experiments

Instruments
This work explores the possibility of using Low Gain Avalanche Diodes (LGADs) for tracker-based experiments studying Charged Cosmic Rays (CCRs) in space.
Ashish Bisht, Leo Cavazzini, Matteo Centis Vignali, Fabiola Caso, Omar Hammad Ali, Francesco Ficorella, Maurizio Boscardin, Giovanni Paternoster   +7 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Characterisation of highly irradiated 3D trench silicon pixel sensors for 4D tracking with 10 ps timing accuracy

Frontiers in Physics
3D trench silicon pixel sensors, recently developed by the TimeSPOT collaboration, have shown excellent performance in terms of spatial resolution, timing precision and detection efficiency.
F. Borgato, F. Borgato, A. Cardini, G. M. Cossu, G. F. Dalla Betta, G. F. Dalla Betta, M. Garau, M. Garau, L. La Delfa, A. Lai, A. Lampis, A. Lampis, A. Loi, M. M. Obertino, M. M. Obertino, G. Simi, G. Simi, S. Vecchi   +17 more
doaj   +1 more source

Particle identification

, 2011
Particle IDentification (PID) is fundamental to particle physics experiments. This paper reviews PID strategies and methods used by the large LHC experiments, which provide outstanding examples of the state-of-the-art.
Lippmann, Christian
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

A Novel Generic Framework for Track Fitting in Complex Detector Systems

, 2010
This paper presents a novel framework for track fitting which is usable in a wide range of experiments, independent of the specific event topology, detector setup, or magnetic field arrangement.
Alexandrescu, B. Ketzer, C. Höppner, Cervera-Villanueva, Frühwirth, Frühwirth, Kalman, Kitagawa, S. Neubert, S. Paul, Spataro, Stroustrup   +11 more
core   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source