Results 101 to 110 of about 2,138,003 (295)

Particle astrophysics from the particle perspective [PDF]

open access: yesAIP Conference Proceedings, 1994
Talk presented at the Lepton-Photon Symposium, 1993, some discussion of axions and anthropic principle revised, 34pp, SCIPP 93 ...
openaire   +2 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Measurements of Light Extinction by Single Aerosol Particles [PDF]

open access: yes, 2013
A Bessel beam optical trap is combined with continuous wave cavity ringdown spectroscopy to measure the extinction cross section of individual aerosol particles.
Reid, Jonathan P.   +3 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Microneedle Coating Techniques for Transdermal Drug Delivery

open access: yesPharmaceutics, 2015
Drug administration via the transdermal route is an evolving field that provides an alternative to oral and parenteral routes of therapy. Several microneedle (MN) based approaches have been developed.
Rita Haj-Ahmad   +8 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Polypeptide components of Drosophila small nuclear ribonucleoprotein particles [PDF]

open access: yes, 1991
In eukaryotes splicing of pre-mRNAs is mediated by the spliceosome, a dynamic complex of small nuclear ribonucleoprotein particles (snRNPs) that associate transiently during spliceosome assembly and the splicing reaction.
FINNEGAN, D J   +4 more
core   +1 more source

Influence of load and reinforcement content on selected tribological properties of Al/SiC/Gr hybrid composites

open access: yesProduction Engineering Archives, 2018
Hybrid materials with the metal matrix are important engineering materials due to their outstanding mechanical and tribological properties. Here are presented selected tribological properties of the hybrid composites with the matrix made of aluminum ...
Veličković Sandra   +5 more
doaj   +1 more source

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