Results 81 to 90 of about 1,225,281 (203)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Probing the Chern–Simons portal at the HL-LHC through displaced vertices from W boson associated production

open access: yesEuropean Physical Journal C: Particles and Fields
This study explores the Chern–Simons portal model, an extension of the Standard Model that introduces a massive neutral vector boson X associated with a $$U_X(1)$$ U X ( 1 ) gauge symmetry.
Mohammad Nourbakhsh   +1 more
doaj   +1 more source

Surface analysis of cannabigerol cocrystals: linking crystal structure to enhanced properties

open access: yesIUCrJ
Cannabigerol is a bioactive compound derived from Cannabis sativa. It displays many promising pharmaceutical and nutraceutical properties. Its use and research are complicated by its thermally unstable solid form with low solubility and needle habit ...
Eliška Zmeškalová   +3 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

open access: yesFEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés   +2 more
wiley   +1 more source

The Propagation of Sunlight and the Size Distribution of Suspended Particles in a Municipally Polluted Ocean Water [PDF]

open access: yes, 1974
Waste discharge by the Los Angeles County Sanitation District (LACSD) affects sunlight in the ocean. Increased sunlight attenuance affects productivity and changes in ocean surface color could be useful for monitoring dispersal. Temperature, sunlight
Peterson, Lee Louis
core   +1 more source

Effect of alkali metal salt addition on disintegration of titania particles precipitated from tetraethyl orthotitanate in ethanol

open access: yesInternational Journal of Ceramic Engineering & Science
Inline (or in situ) photon density wave spectroscopy was used to monitor the disintegration of secondary titania particles into their primary particles.
Sebastian Zimmermann   +3 more
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

open access: yesFEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

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