Results 61 to 70 of about 1,058,569 (267)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Local univalence versus stability and causality in hydrodynamic models

European Physical Journal C: Particles and Fields
Our primary goal is to compare the analytic properties of hydrodynamic series with the stability and causality conditions applied to hydrodynamic modes. Analyticity, in this context, serves as a necessary condition for hydrodynamic series to behave as a ...
Roya Heydari, Farid Taghinavaz
doaj   +1 more source

Research of the influence of technological parameters of thermal diffusion zincaming in the Z_nотх–Al₂O₃ system on the properties and microstructure of the coating

Литьë и металлургия
This article presents the findings of research on the impact of thermal diffusion galvanizing duration and the particle size of zinc dust waste in the galvanizing mixture on the properties and structure of the zinc coating.
N. I. Urbanovich, K. E. Baranovsky, V. G. Dashkevich, A. A. Zhumaev   +3 more
doaj   +1 more source

The Properties of Kaolin from Different Locations and Their Impact on Casting Rate

KONA Powder and Particle Journal, 2019
It has been well known that mineral samples from different locations and origins can exhibit a significant shift in their properties and behavior. The present study of three samples of kaolin from a wide set of origin of deposits, composition, and ...
Mervat Said Hassan Badr, Shuaishuai Yuan, Jiaqi Dong, Hassan El-Shall, Yamile A. Bermudez, Diana C. Ortega, Jorge E. Lopez-Rendon, Brij M. Moudgil   +7 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Probing the Chern–Simons portal at the HL-LHC through displaced vertices from W boson associated production

European Physical Journal C: Particles and Fields
This study explores the Chern–Simons portal model, an extension of the Standard Model that introduces a massive neutral vector boson X associated with a $$U_X(1)$$ U X ( 1 ) gauge symmetry.
Mohammad Nourbakhsh, Mojtaba Mohammadi Najafabadi   +1 more
doaj   +1 more source

Surface analysis of cannabigerol cocrystals: linking crystal structure to enhanced properties

IUCrJ
Cannabigerol is a bioactive compound derived from Cannabis sativa. It displays many promising pharmaceutical and nutraceutical properties. Its use and research are complicated by its thermally unstable solid form with low solubility and needle habit ...
Eliška Zmeškalová, František Stara, Tereza Havlůjová, Miroslav Šoóš   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source