Results 121 to 130 of about 6,183,940 (323)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Microneedle Coating Techniques for Transdermal Drug Delivery
Pharmaceutics, 2015 Drug administration via the transdermal route is an evolving field that provides an alternative to oral and parenteral routes of therapy. Several microneedle (MN) based approaches have been developed.
Rita Haj-Ahmad +8 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Production Engineering Archives, 2018 Hybrid materials with the metal matrix are important engineering materials due to their outstanding mechanical and tribological properties. Here are presented selected tribological properties of the hybrid composites with the matrix made of aluminum ...
Veličković Sandra +5 more
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Fine particles, ultrafine particles.
Hyomen Kagaku, 1989 微粒子・超微粒子の応用は, 触媒, 磁性材料, 電子材料, 光学材料, 焼結材料, 医薬品, 塗料, 顔料など, 驚くほど広い。これらの分野における時代の要請は, 材料の超微粒子化と高品質化にあるともいえる。本稿では, 最近の微粒子・超微粒子の作製技術の進歩, 解析の手法, 超微粒子の形状と変化, および特質と電子状態, そして代表的化学機能である触媒作用について概説した。
openaire +2 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Characterization of charging ability of the silicate minerals [PDF]
Acta Montanistica Slovaca, 2004 To separate granular material it is important to knowi its charging ability. In this contribution the method of charge determination of particles due to the triboelectric charging is described.
Araujo Jose, Marton Karol
doaj
„Malá slova“ a jejich podíl na stylu mluvených projevů
Stylistyka, 2018 In contrast to written language, spoken utterances evince a much higher incidence of deictics, indefinite and pseudo-demonstrative pronouns, contact particles (phatic expressions), specific conjunctions and other connectives, interjections, fillers and ...
Jana Hoffmannová
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Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source