Results 101 to 110 of about 25,407 (286)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Universalism and particularism: philosophical discussions about researching of conspiracy beliefs
Интеллект. Инновации. ИнвестицииIn this article, the authors review current philosophical discussions about the essence and specific features of conspiracy beliefs, the purpose of which is to formulate its relevant definitions.
A. V. Dumov, V. I. Kudashov
doaj +1 more source
Values Underlying the Information Culture in Communist and Post-Communist Russia (1917−1999)
Media and Communication, 2015 In this article the concept of information culture—understood as the dominant handling of information, shared by a dominant proportion of journalists, the public, authorities and other actors within a societal environment at a given time and place—is ...
Hedwig de Smaele
doaj +1 more source
Robustness to fundamental uncertainty in AGI alignment [PDF]
The AGI alignment problem has a bimodal distribution of outcomes with most outcomes clustering around the poles of total success and existential, catastrophic failure.
G. Gordon Worley, I. I. I.
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
The process of microRNAs discovery
Zagadnienia Filozoficzne w Nauce, 2020 The widespread particularist account of the onset of molecular biology that identifies it with the discovery of the DNA structure in 1953 has been recently contested.
Paweł Kawalec
doaj
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Imparcialidad y particularismo moral [PDF]
, 2019 This article aims to present that moral particularism is a viable alternative to the dominant ethics of modernity to the present (i.e., Kantian and utilitarian ethics); theories that have been criticized during the last decades, especially, by the ...
Alegría, Daniela
core
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source