Results 101 to 110 of about 3,459 (300)
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Semantic particularism and linguistic competence
, 2009 In this paper I examine a contemporary debate about the general notion of linguistic rules and the place of context in determining meaning, which has arisen in the wake of a challenge that the con- ceptual framework of moral particularism has brought to ...
Bergqvist, A.
core
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Particularism and presumptive reasons
, 2002 The definitive version is available at www.blackwell-synergy.comWeak particularism about reasons is the view that the normative valency of some descriptive considerations varies, while others have an invariant normative valency.
Cullity, G.
core +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Moral particularism reconfigured
, 2007 The definitive version is available at www.blackwell-synergy.comIn one version, moral particularism says that morality has no need of principles. Jonathan Dancy has argued for this in his recently published Ethics Without Principles.
Gleeson, A., Gleeson, Andrew
core +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Lakatosian Particularism [PDF]
, 2018 This paper explores a particularist element in the theory of method of Imre Lakatos, who appealed to the value-judgements of élite scientists in the appraisal of competing theories of method.
Sankey, Howard
core
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source